A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing
Abstract The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation of inflammation levels, and prevention of bacterial infections. Therefore, a multifunctional wound dressing with antioxidant, local glycocontrol, and antibacterial properties is...
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Wiley
2025-04-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202414161 |
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| author | Bangguo Zhou Yangying Duan Wenhao Li Tao Chen Jincheng Wang Manting Cao Guohao Lin Ke Yang Zhangqi Lai Wencheng Wu |
| author_facet | Bangguo Zhou Yangying Duan Wenhao Li Tao Chen Jincheng Wang Manting Cao Guohao Lin Ke Yang Zhangqi Lai Wencheng Wu |
| author_sort | Bangguo Zhou |
| collection | DOAJ |
| description | Abstract The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation of inflammation levels, and prevention of bacterial infections. Therefore, a multifunctional wound dressing with antioxidant, local glycocontrol, and antibacterial properties is developed to promote diabetic wound healing. This dressing is constructed by co‐loading gold‐cerium oxide (AuCeO2) dumbbells and glucose oxidase (GOx) into a reactive oxygen species (ROS)‐sensitive hydrogel matrix (ACG gels). In this system, Au‐CeO2 dumbbells effectively eliminate ROS, protecting cells from oxidative stress‐induced damage while exhibiting significant near‐infrared photothermal antibacterial activity. Additionally, the controlled release of GOx decreases blood glucose levels in the wound microenvironment, alleviating oxidative stress and inhibiting bacterial growth proliferation, thereby expediting the healing process. ACG gels demonstrated excellent wound healing‐promoting properties in two in vivo wound models, providing a promising and effective platform for diabetic wound management. |
| format | Article |
| id | doaj-art-10979b05ab8049a0b112e9919e6f76d7 |
| institution | DOAJ |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-10979b05ab8049a0b112e9919e6f76d72025-08-20T03:14:12ZengWileyAdvanced Science2198-38442025-04-011216n/an/a10.1002/advs.202414161A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound HealingBangguo Zhou0Yangying Duan1Wenhao Li2Tao Chen3Jincheng Wang4Manting Cao5Guohao Lin6Ke Yang7Zhangqi Lai8Wencheng Wu9Department of Radiology The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang 310003 P. R. ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan 610072 P. R. ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan 610072 P. R. ChinaDepartment of Radiology The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang 310003 P. R. ChinaDepartment of Radiology The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang 310003 P. R. ChinaThe Third School of Clinical Medicine (School of Rehabilitation Medicine) Zhejiang Chinese Medical University Hangzhou 70571 P. R. ChinaThe Third School of Clinical Medicine (School of Rehabilitation Medicine) Zhejiang Chinese Medical University Hangzhou 70571 P. R. ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan 610072 P. R. ChinaThe Third School of Clinical Medicine (School of Rehabilitation Medicine) Zhejiang Chinese Medical University Hangzhou 70571 P. R. ChinaCentral Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan 610072 P. R. ChinaAbstract The management of chronic diabetic wounds is a complex challenge requiring local glycemic regulation, modulation of inflammation levels, and prevention of bacterial infections. Therefore, a multifunctional wound dressing with antioxidant, local glycocontrol, and antibacterial properties is developed to promote diabetic wound healing. This dressing is constructed by co‐loading gold‐cerium oxide (AuCeO2) dumbbells and glucose oxidase (GOx) into a reactive oxygen species (ROS)‐sensitive hydrogel matrix (ACG gels). In this system, Au‐CeO2 dumbbells effectively eliminate ROS, protecting cells from oxidative stress‐induced damage while exhibiting significant near‐infrared photothermal antibacterial activity. Additionally, the controlled release of GOx decreases blood glucose levels in the wound microenvironment, alleviating oxidative stress and inhibiting bacterial growth proliferation, thereby expediting the healing process. ACG gels demonstrated excellent wound healing‐promoting properties in two in vivo wound models, providing a promising and effective platform for diabetic wound management.https://doi.org/10.1002/advs.202414161antioxidantAu‐CeO2 dumbbellsdiabetic wound healinghydrogel dressinglocal glucose managementphotothermal antibacterial |
| spellingShingle | Bangguo Zhou Yangying Duan Wenhao Li Tao Chen Jincheng Wang Manting Cao Guohao Lin Ke Yang Zhangqi Lai Wencheng Wu A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing Advanced Science antioxidant Au‐CeO2 dumbbells diabetic wound healing hydrogel dressing local glucose management photothermal antibacterial |
| title | A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing |
| title_full | A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing |
| title_fullStr | A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing |
| title_full_unstemmed | A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing |
| title_short | A Tailored Hydrogel With Local Glycemia Management, Antioxidant Activity, and Photothermal Antibacterial Properties for Diabetic Wound Healing |
| title_sort | tailored hydrogel with local glycemia management antioxidant activity and photothermal antibacterial properties for diabetic wound healing |
| topic | antioxidant Au‐CeO2 dumbbells diabetic wound healing hydrogel dressing local glucose management photothermal antibacterial |
| url | https://doi.org/10.1002/advs.202414161 |
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