The mechanism of electroacupuncture-mediated improvement in Parkinson’s disease by inhibiting ferroptosis through activating the Nrf2/GPX4 signal pathway

The mechanism of electroacupuncture-mediated improvement in Parkinson’s disease by inhibiting ferroptosis through activating the Nrf2/GPX4 signal pathway

IntroductionFerroptosis, an iron-dependent regulated cell death pathway, shares several features of Parkinson’s disease (PD) physiopathology, and efficient neuroprotective therapies are required to prevent DAergic neuron death initiated by ferroptosis. Electroacupuncture (EA), a treasure of Traditio...

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Bibliographic Details
Main Authors: Min Wang, He-Sheng Zheng, Wei-Liang Ye, Jin-Dong Mao, Kun Zhang, Le Yang, Ming-Gao Zhao, Shui-Bing Liu, Rui Liu, Yu-Mei Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Aging Neuroscience
Subjects:
Parkinson’s disease
ferroptosis
electroacupuncture
nuclear factor erythroid 2-related factor 2
glutathione peroxidase 4
substantia nigra
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1551404/full
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