Antineutrophilic Cytoplasmic Antibody–Positive Vasculitis Associated With Thromboangiitis Obliterans in a Middle-Aged Man
Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitides are autoimmune diseases with multisystem manifestations. We report the case of a 55-year-old Asian man with a history of cigarette smoking who presented with ischemic lesions of the extremities, a positive ANCA, and crescentic glom...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American College of Physicians
2024-05-01
|
| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.1192 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Antineutrophilic cytoplasmic antibody (ANCA)-associated vasculitides are autoimmune diseases with multisystem manifestations. We report the case of a 55-year-old Asian man with a history of cigarette smoking who presented with ischemic lesions of the extremities, a positive ANCA, and crescentic glomerulonephritis. We entertained the diagnosis of ANCA-positive vasculitis associated with thromboangiitis obliterans, a nonatherosclerotic inflammatory vascular disorder. The patient responded well to a combination of immunosuppressive medications and smoking cessation. Cigarette smoking could be a common pathogenic factor in both conditions. To our knowledge, this is the first case of its kind describing an association between ANCA-associated vasculitis and possible thromboangiitis obliterans. |
|---|---|
| ISSN: | 2767-7664 |