Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation
ABSTRACT Objectives Intracranial aneurysm (IA) poses a significant health risk, and its formation involves various factors, including lipid metabolism, while former research only focused on the standard lipid. The purpose of this study is to explore 179 lipid variants' impact on unruptured intr...
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Wiley
2025-03-01
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| Series: | Brain and Behavior |
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| Online Access: | https://doi.org/10.1002/brb3.70435 |
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| author | Junqing Yan |
| author_facet | Junqing Yan |
| author_sort | Junqing Yan |
| collection | DOAJ |
| description | ABSTRACT Objectives Intracranial aneurysm (IA) poses a significant health risk, and its formation involves various factors, including lipid metabolism, while former research only focused on the standard lipid. The purpose of this study is to explore 179 lipid variants' impact on unruptured intracranial aneurysms (uIA). Materials and Methods Utilizing GWAS data for lipids and uIAs, MR analyses were employed with pleiotropy, heterogeneity, and sensitivity tests. Reverse MR analyses were then conducted. Results MR analyses revealed seven lipids associated with uIAs: TAG (51:3). SE (27:1/16:1), PC (18:2_18:2), TAG (48:1), TAG (48:2), and TAG (51:3) were identified as uIA risk factors, while SE (27:1/18:1) and SM (d34:0) exhibited protective effects. Reverse MR analysis showed no bidirectional causal relationships. Conclusions This study identifies specific lipid variants causally linked to uIAs, shedding light on their roles in IA formation. These findings contribute to future research on IA risk assessment and potential therapeutic interventions. |
| format | Article |
| id | doaj-art-108a8a58ac1f4c39a11a0efab3c41a9b |
| institution | DOAJ |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-108a8a58ac1f4c39a11a0efab3c41a9b2025-08-20T03:05:14ZengWileyBrain and Behavior2162-32792025-03-01153n/an/a10.1002/brb3.70435Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm FormationJunqing Yan0Nanxiang Branch of Ruijin Hospital Shanghai ChinaABSTRACT Objectives Intracranial aneurysm (IA) poses a significant health risk, and its formation involves various factors, including lipid metabolism, while former research only focused on the standard lipid. The purpose of this study is to explore 179 lipid variants' impact on unruptured intracranial aneurysms (uIA). Materials and Methods Utilizing GWAS data for lipids and uIAs, MR analyses were employed with pleiotropy, heterogeneity, and sensitivity tests. Reverse MR analyses were then conducted. Results MR analyses revealed seven lipids associated with uIAs: TAG (51:3). SE (27:1/16:1), PC (18:2_18:2), TAG (48:1), TAG (48:2), and TAG (51:3) were identified as uIA risk factors, while SE (27:1/18:1) and SM (d34:0) exhibited protective effects. Reverse MR analysis showed no bidirectional causal relationships. Conclusions This study identifies specific lipid variants causally linked to uIAs, shedding light on their roles in IA formation. These findings contribute to future research on IA risk assessment and potential therapeutic interventions.https://doi.org/10.1002/brb3.70435intracranial aneurysmlipidsMendelian randomizationsingle nucleotide polymorphisms |
| spellingShingle | Junqing Yan Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation Brain and Behavior intracranial aneurysm lipids Mendelian randomization single nucleotide polymorphisms |
| title | Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation |
| title_full | Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation |
| title_fullStr | Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation |
| title_full_unstemmed | Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation |
| title_short | Two‐Sample Mendelian Randomization Analyses Identified Lipid Species Associated With Intracranial Aneurysm Formation |
| title_sort | two sample mendelian randomization analyses identified lipid species associated with intracranial aneurysm formation |
| topic | intracranial aneurysm lipids Mendelian randomization single nucleotide polymorphisms |
| url | https://doi.org/10.1002/brb3.70435 |
| work_keys_str_mv | AT junqingyan twosamplemendelianrandomizationanalysesidentifiedlipidspeciesassociatedwithintracranialaneurysmformation |