Role of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate Immunity
The innate immune system plays a key role in triggering a systemic inflammatory response (SIR). The triggering receptor expressed on myeloid cells (TREM-1), which is located on neutrophils and monocytes, is involved in SIR, by regulating the effector mechanisms of innate immunity. Hyperproduction of...
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| Format: | Article |
| Language: | English |
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Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia
2011-06-01
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| Series: | Общая реаниматология |
| Online Access: | https://www.reanimatology.com/rmt/article/view/306 |
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| author | V. G. Matveyeva A. S. Golovkin E. V. Grigoryev A. V. Ponasenko |
| author_facet | V. G. Matveyeva A. S. Golovkin E. V. Grigoryev A. V. Ponasenko |
| author_sort | V. G. Matveyeva |
| collection | DOAJ |
| description | The innate immune system plays a key role in triggering a systemic inflammatory response (SIR). The triggering receptor expressed on myeloid cells (TREM-1), which is located on neutrophils and monocytes, is involved in SIR, by regulating the effector mechanisms of innate immunity. Hyperproduction of proinflammatory cytokines is a pathogenetic component of the hyperergic phase of acute systemic inflammation. The simultaneous activation of Toll-like receptors and TREM-1 increases the production of cytokines manifold. This is compensatory and adaptive, however, resulting in damage to organs and tissues during excessive production of cytokines. Key words: triggering receptor expressed on myeloid cells, Toll-like receptors, cytokines, inflammation. |
| format | Article |
| id | doaj-art-108679e1a0e847f894ee1bcbae57a0f4 |
| institution | DOAJ |
| issn | 1813-9779 2411-7110 |
| language | English |
| publishDate | 2011-06-01 |
| publisher | Federal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, Russia |
| record_format | Article |
| series | Общая реаниматология |
| spelling | doaj-art-108679e1a0e847f894ee1bcbae57a0f42025-08-20T03:18:50ZengFederal Research and Clinical Center of Intensive Care Medicine and Rehabilitology, Moscow, RussiaОбщая реаниматология1813-97792411-71102011-06-017310.15360/1813-9779-2011-3-70306Role of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate ImmunityV. G. MatveyevaA. S. GolovkinE. V. GrigoryevA. V. PonasenkoThe innate immune system plays a key role in triggering a systemic inflammatory response (SIR). The triggering receptor expressed on myeloid cells (TREM-1), which is located on neutrophils and monocytes, is involved in SIR, by regulating the effector mechanisms of innate immunity. Hyperproduction of proinflammatory cytokines is a pathogenetic component of the hyperergic phase of acute systemic inflammation. The simultaneous activation of Toll-like receptors and TREM-1 increases the production of cytokines manifold. This is compensatory and adaptive, however, resulting in damage to organs and tissues during excessive production of cytokines. Key words: triggering receptor expressed on myeloid cells, Toll-like receptors, cytokines, inflammation.https://www.reanimatology.com/rmt/article/view/306 |
| spellingShingle | V. G. Matveyeva A. S. Golovkin E. V. Grigoryev A. V. Ponasenko Role of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate Immunity Общая реаниматология |
| title | Role of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate Immunity |
| title_full | Role of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate Immunity |
| title_fullStr | Role of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate Immunity |
| title_full_unstemmed | Role of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate Immunity |
| title_short | Role of Triggering Receptor Expressed on Myeloid Cells in the Activation of Innate Immunity |
| title_sort | role of triggering receptor expressed on myeloid cells in the activation of innate immunity |
| url | https://www.reanimatology.com/rmt/article/view/306 |
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