Association between mitral annulus calcification and severity of coronary artery disease assessed by SYNTAX score in patients presented with acute coronary syndrome
ObjectivesMitral annulus calcification (MAC) has been linked to cardiovascular disease severity, but its relationship with the SYNTAX score (SS) in acute coronary syndrome (ACS) patients remains unclear. This study aimed to investigate the association between MAC and SS in ACS patients to explore th...
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Frontiers Media S.A.
2024-10-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1413984/full |
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| author | Afsaneh Esmailpour Soroush Nematollahi Reza Hali Mohammad Sadeghian Sepehr Nayebirad Ahmad Vakili Ahmad Vakili |
| author_facet | Afsaneh Esmailpour Soroush Nematollahi Reza Hali Mohammad Sadeghian Sepehr Nayebirad Ahmad Vakili Ahmad Vakili |
| author_sort | Afsaneh Esmailpour |
| collection | DOAJ |
| description | ObjectivesMitral annulus calcification (MAC) has been linked to cardiovascular disease severity, but its relationship with the SYNTAX score (SS) in acute coronary syndrome (ACS) patients remains unclear. This study aimed to investigate the association between MAC and SS in ACS patients to explore the role of MAC in predicting cardiovascular disease severity.MethodsWe conducted a cross-sectional study of 233 ACS patients at Tehran Heart Center, Tehran, Iran, from December 2021 to August 2022. Patients with prior coronary artery disease (CAD) were excluded. Demographic data, risk factors, and medical history were extracted from clinical files. SS was determined using coronary angiography, and MAC was assessed via two-dimensional transthoracic echocardiography.ResultsThe study population had a mean age of 58.79 years, with 74.7% male. MAC was present in 24.9% of participants, and 57% of those with MAC had an SS above 23. Univariate analysis revealed a significant association between MAC and higher SSs (odds ratio: 1.84, 95% CI: 1.02–3.39; P = 0.046). However, multivariable analysis showed that only left ventricular ejection fraction (LVEF) was independently associated with SS (odds ratio: 0.94, 95% CI: 0.89–0.99; P = 0.015).ConclusionWhile MAC was initially associated with higher SSs in ACS patients, only LVEF emerged as an independent predictor in the multivariable analysis. Although MAC may not be independently associated with SS, it may serve as a useful echocardiographic indicator of more severe CAD in ACS. |
| format | Article |
| id | doaj-art-10650a5712e640a78e32d0ea1dc926b7 |
| institution | OA Journals |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-10650a5712e640a78e32d0ea1dc926b72025-08-20T01:47:50ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-10-011110.3389/fcvm.2024.14139841413984Association between mitral annulus calcification and severity of coronary artery disease assessed by SYNTAX score in patients presented with acute coronary syndromeAfsaneh Esmailpour0Soroush Nematollahi1Reza Hali2Mohammad Sadeghian3Sepehr Nayebirad4Ahmad Vakili5Ahmad Vakili6Tehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranTehran Heart Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, IranDepartment of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, IranObjectivesMitral annulus calcification (MAC) has been linked to cardiovascular disease severity, but its relationship with the SYNTAX score (SS) in acute coronary syndrome (ACS) patients remains unclear. This study aimed to investigate the association between MAC and SS in ACS patients to explore the role of MAC in predicting cardiovascular disease severity.MethodsWe conducted a cross-sectional study of 233 ACS patients at Tehran Heart Center, Tehran, Iran, from December 2021 to August 2022. Patients with prior coronary artery disease (CAD) were excluded. Demographic data, risk factors, and medical history were extracted from clinical files. SS was determined using coronary angiography, and MAC was assessed via two-dimensional transthoracic echocardiography.ResultsThe study population had a mean age of 58.79 years, with 74.7% male. MAC was present in 24.9% of participants, and 57% of those with MAC had an SS above 23. Univariate analysis revealed a significant association between MAC and higher SSs (odds ratio: 1.84, 95% CI: 1.02–3.39; P = 0.046). However, multivariable analysis showed that only left ventricular ejection fraction (LVEF) was independently associated with SS (odds ratio: 0.94, 95% CI: 0.89–0.99; P = 0.015).ConclusionWhile MAC was initially associated with higher SSs in ACS patients, only LVEF emerged as an independent predictor in the multivariable analysis. Although MAC may not be independently associated with SS, it may serve as a useful echocardiographic indicator of more severe CAD in ACS.https://www.frontiersin.org/articles/10.3389/fcvm.2024.1413984/fullmitral annulus calcificationSYNTAX scorecoronary artery diseaseacute coronary syndromeangiography |
| spellingShingle | Afsaneh Esmailpour Soroush Nematollahi Reza Hali Mohammad Sadeghian Sepehr Nayebirad Ahmad Vakili Ahmad Vakili Association between mitral annulus calcification and severity of coronary artery disease assessed by SYNTAX score in patients presented with acute coronary syndrome Frontiers in Cardiovascular Medicine mitral annulus calcification SYNTAX score coronary artery disease acute coronary syndrome angiography |
| title | Association between mitral annulus calcification and severity of coronary artery disease assessed by SYNTAX score in patients presented with acute coronary syndrome |
| title_full | Association between mitral annulus calcification and severity of coronary artery disease assessed by SYNTAX score in patients presented with acute coronary syndrome |
| title_fullStr | Association between mitral annulus calcification and severity of coronary artery disease assessed by SYNTAX score in patients presented with acute coronary syndrome |
| title_full_unstemmed | Association between mitral annulus calcification and severity of coronary artery disease assessed by SYNTAX score in patients presented with acute coronary syndrome |
| title_short | Association between mitral annulus calcification and severity of coronary artery disease assessed by SYNTAX score in patients presented with acute coronary syndrome |
| title_sort | association between mitral annulus calcification and severity of coronary artery disease assessed by syntax score in patients presented with acute coronary syndrome |
| topic | mitral annulus calcification SYNTAX score coronary artery disease acute coronary syndrome angiography |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1413984/full |
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