Identifying genetic variants that affect viability in large cohorts.

Identifying genetic variants that affect viability in large cohorts.

A number of open questions in human evolutionary genetics would become tractable if we were able to directly measure evolutionary fitness. As a step towards this goal, we developed a method to examine whether individual genetic variants, or sets of genetic variants, currently influence viability. Th...

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Bibliographic Details
Main Authors: Hakhamanesh Mostafavi, Tomaz Berisa, Felix R Day, John R B Perry, Molly Przeworski, Joseph K Pickrell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-09-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.2002458&type=printable
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