Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges
PURPOSEThe global burden of lymphoma is substantial because of the increase in its incidence in recent decades. However, disease characteristics vary across different geographical locations. Numerous immunohistochemistry markers and molecular studies are essential to determine lymphoma diagnosis and...
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American Society of Clinical Oncology
2024-10-01
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| Series: | JCO Global Oncology |
| Online Access: | https://ascopubs.org/doi/10.1200/GO-24-00346 |
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| author | Agnes Stephanie Harahap Maria Francisca Ham Andree Kurniawan Stefanny Charles Felix Wijovi Lugyanti Sukrisman |
| author_facet | Agnes Stephanie Harahap Maria Francisca Ham Andree Kurniawan Stefanny Charles Felix Wijovi Lugyanti Sukrisman |
| author_sort | Agnes Stephanie Harahap |
| collection | DOAJ |
| description | PURPOSEThe global burden of lymphoma is substantial because of the increase in its incidence in recent decades. However, disease characteristics vary across different geographical locations. Numerous immunohistochemistry markers and molecular studies are essential to determine lymphoma diagnosis and prognosis. This poses significant challenges in developing countries with limited health care resources. This large-scale study assesses the frequency of non-Hodgkin lymphoma (NHL) in Indonesia over the past 15 years, analyses its clinicopathologic features, and predicts future trends.METHODSThis retrospective study collected lymphoma patients diagnosed at the Department of Anatomical Pathology Dr. Cipto Mangunkusumo National Central General Hospital, Indonesia, from 2009 until 2023. All lymphoma diagnoses were confirmed by using ancillary tools classified as an enhanced lymphoma panel according to a resource-stratified guideline. We analyzed the clinicopathologic features of each NHL type and further applied the Autoregressive Integrated Moving Average model to predict future incidence trends.RESULTSThe study consisted of 7,368 NHL patients. Among these, B-cell lymphomas accounted for 90.6%, with diffuse large B-cell lymphoma being the most prevalent subtype (68.8%), followed by follicular lymphoma (8.8%) and marginal zone lymphoma (5.8%). Extranodal natural killer/T-cell lymphoma, nasal type, is the most common T-cell lymphoma found (26.3%). All types of lymphoma were found to be more common in males (57.7%). Extranodal involvement, particularly in the tonsil and upper respiratory tract, was frequently observed. Projection analysis indicates a steady increase in lymphoma patients in the future.CONCLUSIONThis study highlights the distribution and burden of NHL in Indonesia over 15 years. The overall epidemiologic pattern of NHL in this study aligns with the results observed in other Asian countries. The rising incidence of lymphoma requires improved health care infrastructure and prevention strategies. |
| format | Article |
| id | doaj-art-1055f17012e44cb48330061bb3cd6599 |
| institution | OA Journals |
| issn | 2687-8941 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | American Society of Clinical Oncology |
| record_format | Article |
| series | JCO Global Oncology |
| spelling | doaj-art-1055f17012e44cb48330061bb3cd65992025-08-20T02:12:54ZengAmerican Society of Clinical OncologyJCO Global Oncology2687-89412024-10-011010.1200/GO-24-00346Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic ChallengesAgnes Stephanie Harahap0Maria Francisca Ham1Andree Kurniawan2Stefanny Charles3Felix Wijovi4Lugyanti Sukrisman5Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, IndonesiaAnatomical Pathology Department, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, IndonesiaSubspecialist Program Study, Hematology and Medical Oncology, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, IndonesiaHuman Cancer Research Center-Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaHuman Cancer Research Center-Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaHematology and Medical Oncology, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, IndonesiaPURPOSEThe global burden of lymphoma is substantial because of the increase in its incidence in recent decades. However, disease characteristics vary across different geographical locations. Numerous immunohistochemistry markers and molecular studies are essential to determine lymphoma diagnosis and prognosis. This poses significant challenges in developing countries with limited health care resources. This large-scale study assesses the frequency of non-Hodgkin lymphoma (NHL) in Indonesia over the past 15 years, analyses its clinicopathologic features, and predicts future trends.METHODSThis retrospective study collected lymphoma patients diagnosed at the Department of Anatomical Pathology Dr. Cipto Mangunkusumo National Central General Hospital, Indonesia, from 2009 until 2023. All lymphoma diagnoses were confirmed by using ancillary tools classified as an enhanced lymphoma panel according to a resource-stratified guideline. We analyzed the clinicopathologic features of each NHL type and further applied the Autoregressive Integrated Moving Average model to predict future incidence trends.RESULTSThe study consisted of 7,368 NHL patients. Among these, B-cell lymphomas accounted for 90.6%, with diffuse large B-cell lymphoma being the most prevalent subtype (68.8%), followed by follicular lymphoma (8.8%) and marginal zone lymphoma (5.8%). Extranodal natural killer/T-cell lymphoma, nasal type, is the most common T-cell lymphoma found (26.3%). All types of lymphoma were found to be more common in males (57.7%). Extranodal involvement, particularly in the tonsil and upper respiratory tract, was frequently observed. Projection analysis indicates a steady increase in lymphoma patients in the future.CONCLUSIONThis study highlights the distribution and burden of NHL in Indonesia over 15 years. The overall epidemiologic pattern of NHL in this study aligns with the results observed in other Asian countries. The rising incidence of lymphoma requires improved health care infrastructure and prevention strategies.https://ascopubs.org/doi/10.1200/GO-24-00346 |
| spellingShingle | Agnes Stephanie Harahap Maria Francisca Ham Andree Kurniawan Stefanny Charles Felix Wijovi Lugyanti Sukrisman Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges JCO Global Oncology |
| title | Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges |
| title_full | Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges |
| title_fullStr | Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges |
| title_full_unstemmed | Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges |
| title_short | Fifteen Years of Non-Hodgkin Lymphoma in an Indonesian National Referral Hospital: Epidemiologic Trends and Diagnostic Challenges |
| title_sort | fifteen years of non hodgkin lymphoma in an indonesian national referral hospital epidemiologic trends and diagnostic challenges |
| url | https://ascopubs.org/doi/10.1200/GO-24-00346 |
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