Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors Scanning
Purpose: The quality of the image in SPECT scans depends on the imaging parameters which are determined experimentally in the field of nuclear medicine. Designing a dedicated scanning parameter for 177Lu-DOTATATE SPECT images is required to optimize reconstruction. Therefore, this study aims to eva...
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Tehran University of Medical Sciences
2025-01-01
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| Series: | Frontiers in Biomedical Technologies |
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| Online Access: | https://fbt.tums.ac.ir/index.php/fbt/article/view/422 |
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| author | Hussein Dakhil Mohammad Reza Deevband Mahasti Amoui Ahmad Mostaar Mahdi Ghorbani Mohsen Khosroabadi Mohammad Ali Ghodsirad |
| author_facet | Hussein Dakhil Mohammad Reza Deevband Mahasti Amoui Ahmad Mostaar Mahdi Ghorbani Mohsen Khosroabadi Mohammad Ali Ghodsirad |
| author_sort | Hussein Dakhil |
| collection | DOAJ |
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Purpose: The quality of the image in SPECT scans depends on the imaging parameters which are determined experimentally in the field of nuclear medicine. Designing a dedicated scanning parameter for 177Lu-DOTATATE SPECT images is required to optimize reconstruction. Therefore, this study aims to evaluate the effect of different filters on image quality for bone SPECT scanning using 177Lu-DOTATATE.
Materials and Methods: The filtered back-projection reconstruction method was used in neuro-endocrine tumor scanning using 177Lu-DOTATATE. Three hours after injection of 177Lu-DOTATATE, SPECT scans from 177Lu-DOTATATE for 30 patients were acquired using a dual-head EvoExel detector system. Seven parameters were considered, including the contrast/noise ratio, injection activity, uptake duration, acquisition time per injection, frame time, measuring time, and type of filters.
Results: In all cases, the application of different filters increased Contrast to Noise Ratio (CNR) (9.1%, 1.8%, 10.9%, 61.8%, 23.6%, 29.1%, and 58.2% for Wiener, Butterworth, Parzen, Metz, Ramp, Shepp-Logan, and Hamming filters, respectively). The percentage of increase in Signal-to-Noise Ratio (SNR) was 3.3%, 1.7%, -24%, 21.7%, 9.8%, 11.9%, and 20.6%.
Conclusion: Based on the quantitative analysis of the results, the application of the Metz filter (power 2) and Hamming filter (with 0.27, 0.47, and 0.67 cut-off frequencies) on SPECT scans of neuro-endocrine tumors is recommended because of their capacity to provide high-quality images.
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| format | Article |
| id | doaj-art-1041f0278d2b4f70a8cdb60791fc54f3 |
| institution | Kabale University |
| issn | 2345-5837 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Frontiers in Biomedical Technologies |
| spelling | doaj-art-1041f0278d2b4f70a8cdb60791fc54f32025-02-09T08:56:03ZengTehran University of Medical SciencesFrontiers in Biomedical Technologies2345-58372025-01-0112110.18502/fbt.v12i1.17727Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors ScanningHussein Dakhil0Mohammad Reza Deevband1Mahasti Amoui2Ahmad Mostaar3Mahdi Ghorbani4Mohsen Khosroabadi5Mohammad Ali Ghodsirad6Department of Bioengineering and Medical Physics, Shahid-Beheshti University of Medical Sciences, Tehran, IranDepartment of Bioengineering and Medical Physics, Shahid-Beheshti University of Medical Sciences, Tehran, IranDepartment of Bioengineering and Medical Physics, Shahid-Beheshti University of Medical Sciences, Tehran, IranDepartment of Bioengineering and Medical Physics, Shahid-Beheshti University of Medical Sciences, Tehran, IranBiomedical Engineering and Medical Physics Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IranDepartment of Medical Physics, North Khorasan University of Medical Sciences, Bojnurd, IranNuclear Medicine Department, Shohada-e-Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Purpose: The quality of the image in SPECT scans depends on the imaging parameters which are determined experimentally in the field of nuclear medicine. Designing a dedicated scanning parameter for 177Lu-DOTATATE SPECT images is required to optimize reconstruction. Therefore, this study aims to evaluate the effect of different filters on image quality for bone SPECT scanning using 177Lu-DOTATATE. Materials and Methods: The filtered back-projection reconstruction method was used in neuro-endocrine tumor scanning using 177Lu-DOTATATE. Three hours after injection of 177Lu-DOTATATE, SPECT scans from 177Lu-DOTATATE for 30 patients were acquired using a dual-head EvoExel detector system. Seven parameters were considered, including the contrast/noise ratio, injection activity, uptake duration, acquisition time per injection, frame time, measuring time, and type of filters. Results: In all cases, the application of different filters increased Contrast to Noise Ratio (CNR) (9.1%, 1.8%, 10.9%, 61.8%, 23.6%, 29.1%, and 58.2% for Wiener, Butterworth, Parzen, Metz, Ramp, Shepp-Logan, and Hamming filters, respectively). The percentage of increase in Signal-to-Noise Ratio (SNR) was 3.3%, 1.7%, -24%, 21.7%, 9.8%, 11.9%, and 20.6%. Conclusion: Based on the quantitative analysis of the results, the application of the Metz filter (power 2) and Hamming filter (with 0.27, 0.47, and 0.67 cut-off frequencies) on SPECT scans of neuro-endocrine tumors is recommended because of their capacity to provide high-quality images. https://fbt.tums.ac.ir/index.php/fbt/article/view/422Nuclear MedicineImage ReconstructionFilter DesignImage QualitySingle Photon Emission Computed Tomography Imaging |
| spellingShingle | Hussein Dakhil Mohammad Reza Deevband Mahasti Amoui Ahmad Mostaar Mahdi Ghorbani Mohsen Khosroabadi Mohammad Ali Ghodsirad Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors Scanning Frontiers in Biomedical Technologies Nuclear Medicine Image Reconstruction Filter Design Image Quality Single Photon Emission Computed Tomography Imaging |
| title | Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors Scanning |
| title_full | Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors Scanning |
| title_fullStr | Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors Scanning |
| title_full_unstemmed | Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors Scanning |
| title_short | Filters Effect on Image Quality of 177Lu-DOTATATE SPECT Images for Neuro-Endocrine Tumors Scanning |
| title_sort | filters effect on image quality of 177lu dotatate spect images for neuro endocrine tumors scanning |
| topic | Nuclear Medicine Image Reconstruction Filter Design Image Quality Single Photon Emission Computed Tomography Imaging |
| url | https://fbt.tums.ac.ir/index.php/fbt/article/view/422 |
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