Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives
ABSTRACT Background Type 2 diabetes mellitus (T2D) is a growing metabolic disorder affecting all age groups and is linked to testiculopathy, a key contributor to male infertility. Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic adenosine monophosphate (cAMP) r...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Reproductive Medicine and Biology |
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| Online Access: | https://doi.org/10.1002/rmb2.12661 |
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| author | Olabimpe Caroline Badejogbin Oyedayo Phillips Akano Oluwafisayo Elizabeth Boluwatife Julius Mary Olaoluwa Agunloye Makinde Vincent Olubiyi Ojichukwuka Ebere Chijioke‐Agu Matthew Agene Obekpa Adesina Paul Arikawe Kehinde Samuel Olaniyi |
| author_facet | Olabimpe Caroline Badejogbin Oyedayo Phillips Akano Oluwafisayo Elizabeth Boluwatife Julius Mary Olaoluwa Agunloye Makinde Vincent Olubiyi Ojichukwuka Ebere Chijioke‐Agu Matthew Agene Obekpa Adesina Paul Arikawe Kehinde Samuel Olaniyi |
| author_sort | Olabimpe Caroline Badejogbin |
| collection | DOAJ |
| description | ABSTRACT Background Type 2 diabetes mellitus (T2D) is a growing metabolic disorder affecting all age groups and is linked to testiculopathy, a key contributor to male infertility. Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic adenosine monophosphate (cAMP) response element modulator (CREM) playing a pivotal role in testicular function. Understanding the interplay between T2D and CREM dysregulation is essential for developing targeted therapies for diabetic testicular dysfunction. Methods A systematic review of PubMed, Web of Science, Scopus, and Google Scholar was conducted to identify peer‐reviewed studies, both preclinical and clinical, that explored CREM's role in diabetes‐induced testicular dysfunction. Extracted data focused on CREM expression, oxidative stress, apoptosis, and spermatogenic impairment in diabetic models. Main Findings Research from studies on diabetic patients and animal models highlights the detrimental effects of diabetes on the reproductive system, including hypothalamic–pituitary–testicular (HPT) axis dysregulation. CREM regulates spermatogenic gene expression, influenced by luteinizing hormone (LH), follicle‐stimulating hormone (FSH), and cAMP signaling. Conclusion CREM has a therapeutic role in maintaining testicular function, and its disruption may contribute to testiculopathy in T2D, highlighting its potential therapeutic target for preserving male fertility in diabetic patients. Further research is needed to explore its molecular mechanisms and therapeutic implications. |
| format | Article |
| id | doaj-art-1041de28cfcc40a180e97616d08537ff |
| institution | Kabale University |
| issn | 1445-5781 1447-0578 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj-art-1041de28cfcc40a180e97616d08537ff2025-08-20T06:16:47ZengWileyReproductive Medicine and Biology1445-57811447-05782025-01-01241n/an/a10.1002/rmb2.12661Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future PerspectivesOlabimpe Caroline Badejogbin0Oyedayo Phillips Akano1Oluwafisayo Elizabeth Boluwatife Julius2Mary Olaoluwa Agunloye3Makinde Vincent Olubiyi4Ojichukwuka Ebere Chijioke‐Agu5Matthew Agene Obekpa6Adesina Paul Arikawe7Kehinde Samuel Olaniyi8Department of Physiology College of Basic Medical Sciences, Babcock University Ilishan‐Remo Ogun State NigeriaDepartment of Physiology College of Basic Medical Sciences, Babcock University Ilishan‐Remo Ogun State NigeriaDepartment of Physiology College of Basic Medical Sciences, Babcock University Ilishan‐Remo Ogun State NigeriaDepartment of Physiology Kampala International University, Western Campus Ishaka UgandaDepartment of Medical Physiology University of Rwanda Huye RwandaDepartment of Physiology Alex‐Ekwueme Federal University Abakaliki Ebonyi State NigeriaDepartment of Physiology University of Ilorin Ilorin Kwara State NigeriaDepartment of Physiology College of Medicine, University of Lagos State Idi‐Araba Lagos State NigeriaDepartment of Physiology College of Medicine and Health Sciences, Afe Babalola University Ado‐Ekiti Ekiti State NigeriaABSTRACT Background Type 2 diabetes mellitus (T2D) is a growing metabolic disorder affecting all age groups and is linked to testiculopathy, a key contributor to male infertility. Testiculopathy disrupts spermatogenesis and the sperm microenvironment, with the cyclic adenosine monophosphate (cAMP) response element modulator (CREM) playing a pivotal role in testicular function. Understanding the interplay between T2D and CREM dysregulation is essential for developing targeted therapies for diabetic testicular dysfunction. Methods A systematic review of PubMed, Web of Science, Scopus, and Google Scholar was conducted to identify peer‐reviewed studies, both preclinical and clinical, that explored CREM's role in diabetes‐induced testicular dysfunction. Extracted data focused on CREM expression, oxidative stress, apoptosis, and spermatogenic impairment in diabetic models. Main Findings Research from studies on diabetic patients and animal models highlights the detrimental effects of diabetes on the reproductive system, including hypothalamic–pituitary–testicular (HPT) axis dysregulation. CREM regulates spermatogenic gene expression, influenced by luteinizing hormone (LH), follicle‐stimulating hormone (FSH), and cAMP signaling. Conclusion CREM has a therapeutic role in maintaining testicular function, and its disruption may contribute to testiculopathy in T2D, highlighting its potential therapeutic target for preserving male fertility in diabetic patients. Further research is needed to explore its molecular mechanisms and therapeutic implications.https://doi.org/10.1002/rmb2.12661CREMmale infertilityreproductionspermatogenesistesticulopathytype 2 diabetes mellitus |
| spellingShingle | Olabimpe Caroline Badejogbin Oyedayo Phillips Akano Oluwafisayo Elizabeth Boluwatife Julius Mary Olaoluwa Agunloye Makinde Vincent Olubiyi Ojichukwuka Ebere Chijioke‐Agu Matthew Agene Obekpa Adesina Paul Arikawe Kehinde Samuel Olaniyi Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives Reproductive Medicine and Biology CREM male infertility reproduction spermatogenesis testiculopathy type 2 diabetes mellitus |
| title | Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives |
| title_full | Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives |
| title_fullStr | Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives |
| title_full_unstemmed | Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives |
| title_short | Potential Role of CREM in Diabetes‐Associated Testicular Dysfunction: Current Evidence and Future Perspectives |
| title_sort | potential role of crem in diabetes associated testicular dysfunction current evidence and future perspectives |
| topic | CREM male infertility reproduction spermatogenesis testiculopathy type 2 diabetes mellitus |
| url | https://doi.org/10.1002/rmb2.12661 |
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