A single-dose intranasal immunization with a novel bat influenza A virus-vectored MERS vaccine provides effective protection against lethal MERS-CoV challenge

A single-dose intranasal immunization with a novel bat influenza A virus-vectored MERS vaccine provides effective protection against lethal MERS-CoV challenge

ABSTRACT The threat to global health security posed by Middle East respiratory syndrome coronavirus (MERS-CoV) and emerging MERS-like coronaviruses highlights the need to develop safe and efficient vaccines. Viral vector vaccines have been shown to be effective and are widely used to prevent various...

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Bibliographic Details
Main Authors: Lei Shi, Sawrab Roy, Yuekun Lang, Yuhan Wen, William J. Mitchell, Wenyu Yang, Liping Wang, Jialin Zhang, Heidi Liu, John P. Driver, Malik Peiris, Wenjun Ma
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:mBio
Subjects:
MERS-CoV
bat influenza vectored MERS vaccine
safety and immunogenicity
cross-protection
Online Access:https://journals.asm.org/doi/10.1128/mbio.01107-25
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