Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case Report
Introduction. Autoimmune encephalitis is caused by antineuronal immune mechanisms. Its clinical presentation is heterogeneous and in many cases onset with psychiatric symptoms. Paraclinical criteria guide the approach; however, the challenge occurs when there are no detectable autoantibodies in seru...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Case Reports in Psychiatry |
| Online Access: | http://dx.doi.org/10.1155/2022/2460492 |
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| author | Miguel Soto Ontoso Ruben A. Piernas González Isabel Ramírez Martínez José Miguel Meca García |
| author_facet | Miguel Soto Ontoso Ruben A. Piernas González Isabel Ramírez Martínez José Miguel Meca García |
| author_sort | Miguel Soto Ontoso |
| collection | DOAJ |
| description | Introduction. Autoimmune encephalitis is caused by antineuronal immune mechanisms. Its clinical presentation is heterogeneous and in many cases onset with psychiatric symptoms. Paraclinical criteria guide the approach; however, the challenge occurs when there are no detectable autoantibodies in serum or cerebrospinal fluid (CSF). Methodology. We report one case that highlights the variability of clinical manifestations, which in the absence of antibodies was treated with immunotherapy with good response. Conclusion. In places where there is no antibody measurement, or when its measurement is negative, the clinical suspicion supported by CSF studies, magnetic resonance imaging, and electroencephalographic recording, should guide us to start immunotherapeutic treatment early. The early initiation of treatment ensures the reversibility of the neurological disorder in the vast majority of patients. |
| format | Article |
| id | doaj-art-1036e86ef5314f419efff6a2f8d9fa12 |
| institution | Kabale University |
| issn | 2090-6838 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Psychiatry |
| spelling | doaj-art-1036e86ef5314f419efff6a2f8d9fa122025-02-03T06:13:31ZengWileyCase Reports in Psychiatry2090-68382022-01-01202210.1155/2022/2460492Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case ReportMiguel Soto Ontoso0Ruben A. Piernas González1Isabel Ramírez Martínez2José Miguel Meca García3Department of PsychiatryDepartment of PsychiatryDepartment of PsychiatryDepartment of PsychiatryIntroduction. Autoimmune encephalitis is caused by antineuronal immune mechanisms. Its clinical presentation is heterogeneous and in many cases onset with psychiatric symptoms. Paraclinical criteria guide the approach; however, the challenge occurs when there are no detectable autoantibodies in serum or cerebrospinal fluid (CSF). Methodology. We report one case that highlights the variability of clinical manifestations, which in the absence of antibodies was treated with immunotherapy with good response. Conclusion. In places where there is no antibody measurement, or when its measurement is negative, the clinical suspicion supported by CSF studies, magnetic resonance imaging, and electroencephalographic recording, should guide us to start immunotherapeutic treatment early. The early initiation of treatment ensures the reversibility of the neurological disorder in the vast majority of patients.http://dx.doi.org/10.1155/2022/2460492 |
| spellingShingle | Miguel Soto Ontoso Ruben A. Piernas González Isabel Ramírez Martínez José Miguel Meca García Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case Report Case Reports in Psychiatry |
| title | Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case Report |
| title_full | Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case Report |
| title_fullStr | Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case Report |
| title_full_unstemmed | Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case Report |
| title_short | Clinical Diagnosis of an Autoimmune Encephalitis Presented as a Manic Episode with Psychotic Symptoms: A Case Report |
| title_sort | clinical diagnosis of an autoimmune encephalitis presented as a manic episode with psychotic symptoms a case report |
| url | http://dx.doi.org/10.1155/2022/2460492 |
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