Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study.
<h4>Background</h4>A role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but studies on cervical adenocarcinoma are limited.<h4>Methods</h4>A total of 1,553 cervical smears taken up to 26 years before diagnosis in a large...
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156215&type=printable |
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| author | Vitaly Smelov Tarik Gheit Karin Sundström Alexander Ploner Sandrine McKay-Chopin Carina Eklund Massimo Tommasino Joakim Dillner |
| author_facet | Vitaly Smelov Tarik Gheit Karin Sundström Alexander Ploner Sandrine McKay-Chopin Carina Eklund Massimo Tommasino Joakim Dillner |
| author_sort | Vitaly Smelov |
| collection | DOAJ |
| description | <h4>Background</h4>A role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but studies on cervical adenocarcinoma are limited.<h4>Methods</h4>A total of 1,553 cervical smears taken up to 26 years before diagnosis in a large population-based nested case-control study of cervical adenocarcinoma (AC, 132 cases with matched controls), and adenocarcinoma in situ (AIS, 159 cases with matched controls) were tested for C. trachomatis and HPV DNA by a type-specific PCR bead-based multiplex genotyping (TS-MPG) assay.<h4>Results</h4>Only 1.7% of samples were positive for C. trachomatis, with no significant differences between AC/AIS cases and controls. HPV-positivity was detected in 49.3% of C. trachomatis-negative and 65.4% C. trachomatis-positive samples, respectively.<h4>Conclusions</h4>A large prospective study did not find any risk for cervical adenocarcinoma and/or AIS conferred by C. trachomatis infection.<h4>Impact</h4>C. trachomatis appears not to be involved in cervical adenocarcinomas. |
| format | Article |
| id | doaj-art-10369c889a414edab7e9d0dd2bb6faee |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-10369c889a414edab7e9d0dd2bb6faee2025-08-20T02:03:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015621510.1371/journal.pone.0156215Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study.Vitaly SmelovTarik GheitKarin SundströmAlexander PlonerSandrine McKay-ChopinCarina EklundMassimo TommasinoJoakim Dillner<h4>Background</h4>A role of Chlamydia trachomatis in HPV-induced cervical carcinogenesis has been reported for cervical cancer but studies on cervical adenocarcinoma are limited.<h4>Methods</h4>A total of 1,553 cervical smears taken up to 26 years before diagnosis in a large population-based nested case-control study of cervical adenocarcinoma (AC, 132 cases with matched controls), and adenocarcinoma in situ (AIS, 159 cases with matched controls) were tested for C. trachomatis and HPV DNA by a type-specific PCR bead-based multiplex genotyping (TS-MPG) assay.<h4>Results</h4>Only 1.7% of samples were positive for C. trachomatis, with no significant differences between AC/AIS cases and controls. HPV-positivity was detected in 49.3% of C. trachomatis-negative and 65.4% C. trachomatis-positive samples, respectively.<h4>Conclusions</h4>A large prospective study did not find any risk for cervical adenocarcinoma and/or AIS conferred by C. trachomatis infection.<h4>Impact</h4>C. trachomatis appears not to be involved in cervical adenocarcinomas.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156215&type=printable |
| spellingShingle | Vitaly Smelov Tarik Gheit Karin Sundström Alexander Ploner Sandrine McKay-Chopin Carina Eklund Massimo Tommasino Joakim Dillner Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study. PLoS ONE |
| title | Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study. |
| title_full | Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study. |
| title_fullStr | Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study. |
| title_full_unstemmed | Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study. |
| title_short | Lack of Significant Effects of Chlamydia trachomatis Infection on Cervical Adenocarcinoma Risk: Nested Case-Control Study. |
| title_sort | lack of significant effects of chlamydia trachomatis infection on cervical adenocarcinoma risk nested case control study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156215&type=printable |
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