Variable Clinical Phenotypes of α-Thalassemia Syndromes
Genetic mutations of the α genes are common worldwide. In Asia and particularly Southeast Asia, they can result in clinically significant types of α-thalassemia, namely hemoglobin (Hb) H disease and Hb Bart's hydrops fetalis. The latter is generally a fatal intrauterine condition, while Hb H di...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2009.69 |
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| _version_ | 1849304475266711552 |
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| author | Sylvia Titi Singer |
| author_facet | Sylvia Titi Singer |
| author_sort | Sylvia Titi Singer |
| collection | DOAJ |
| description | Genetic mutations of the α genes are common worldwide. In Asia and particularly Southeast Asia, they can result in clinically significant types of α-thalassemia, namely hemoglobin (Hb) H disease and Hb Bart's hydrops fetalis. The latter is generally a fatal intrauterine condition, while Hb H disease results in clinical complications that are frequently overlooked. The high prevalence of the carrier state and the burden of these diseases (and other α-thalassemia variants) call for more attention for improved screening methods and better care. |
| format | Article |
| id | doaj-art-10325fa3dfd5437caf7b156d8718ff84 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-10325fa3dfd5437caf7b156d8718ff842025-08-20T03:55:44ZengWileyThe Scientific World Journal1537-744X2009-01-01961562510.1100/tsw.2009.69Variable Clinical Phenotypes of α-Thalassemia SyndromesSylvia Titi Singer0Hematology/Oncology Department, Children's Hospital and Research Center (CHRCO), Oakland, CA, United StatesGenetic mutations of the α genes are common worldwide. In Asia and particularly Southeast Asia, they can result in clinically significant types of α-thalassemia, namely hemoglobin (Hb) H disease and Hb Bart's hydrops fetalis. The latter is generally a fatal intrauterine condition, while Hb H disease results in clinical complications that are frequently overlooked. The high prevalence of the carrier state and the burden of these diseases (and other α-thalassemia variants) call for more attention for improved screening methods and better care.http://dx.doi.org/10.1100/tsw.2009.69 |
| spellingShingle | Sylvia Titi Singer Variable Clinical Phenotypes of α-Thalassemia Syndromes The Scientific World Journal |
| title | Variable Clinical Phenotypes of α-Thalassemia Syndromes |
| title_full | Variable Clinical Phenotypes of α-Thalassemia Syndromes |
| title_fullStr | Variable Clinical Phenotypes of α-Thalassemia Syndromes |
| title_full_unstemmed | Variable Clinical Phenotypes of α-Thalassemia Syndromes |
| title_short | Variable Clinical Phenotypes of α-Thalassemia Syndromes |
| title_sort | variable clinical phenotypes of α thalassemia syndromes |
| url | http://dx.doi.org/10.1100/tsw.2009.69 |
| work_keys_str_mv | AT sylviatitisinger variableclinicalphenotypesofathalassemiasyndromes |