The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation

The MICA‐129 dimorphism affects NKG2D signaling and outcome of hematopoietic stem cell transplantation

Abstract The MHC class I chain‐related molecule A (MICA) is a highly polymorphic ligand for the activating natural killer (NK)‐cell receptor NKG2D. A single nucleotide polymorphism causes a valine to methionine exchange at position 129. Presence of a MICA‐129Met allele in patients (n = 452) undergoi...

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Main Authors: Antje Isernhagen, Dörthe Malzahn, Elena Viktorova, Leslie Elsner, Sebastian Monecke, Frederike von Bonin, Markus Kilisch, Janne Marieke Wermuth, Neele Walther, Yesilda Balavarca, Christiane Stahl‐Hennig, Michael Engelke, Lutz Walter, Heike Bickeböller, Dieter Kube, Gerald Wulf, Ralf Dressel
Format: Article
Language:English
Published: Springer Nature 2015-10-01
Series:EMBO Molecular Medicine
Subjects:
cytotoxic T cells
graft‐versus‐host disease
NK‐cell receptors
NK cells
single nucleotide polymorphism
Online Access:https://doi.org/10.15252/emmm.201505246
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