Vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus: a pilot cross-sectional study from Thailand
Objective The risk factors associated with urinary tract infections (UTIs) in patients with SLE remain uncertain. We evaluated the vaginal microbiota pattern and its potential UTI-associated risk factors.Methods A pilot cross-sectional study of patients with SLE was conducted at Ramathibodi Hospital...
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| Format: | Article |
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BMJ Publishing Group
2021-04-01
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| Series: | Lupus Science and Medicine |
| Online Access: | https://lupus.bmj.com/content/8/1/e000551.full |
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| author | Prapaporn Pisitkun Pintip Ngamjanyaporn Porpon Rotjanapan Aunyakant Jaroensukrungruang Jittima Manonai Vorthon Sawaswong Prangwalai Chanchaem Sunchai Payungporn |
| author_facet | Prapaporn Pisitkun Pintip Ngamjanyaporn Porpon Rotjanapan Aunyakant Jaroensukrungruang Jittima Manonai Vorthon Sawaswong Prangwalai Chanchaem Sunchai Payungporn |
| author_sort | Prapaporn Pisitkun |
| collection | DOAJ |
| description | Objective The risk factors associated with urinary tract infections (UTIs) in patients with SLE remain uncertain. We evaluated the vaginal microbiota pattern and its potential UTI-associated risk factors.Methods A pilot cross-sectional study of patients with SLE was conducted at Ramathibodi Hospital, Bangkok, Thailand, during 2019–2020. Patients’ demographic data and relevant information were collected. Vaginal microbiota was assessed in all patients and in 10 healthy volunteers.Results Fifty-two patients were enrolled (mean age: 46.1 years). All patients had SLE that was in low disease activity. As per the Simpson_e index, the within-group alpha diversity of the vaginal microbiota was low in the SLE with UTI and SLE receiving trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis groups. Multivariate logistic regression analysis revealed that TMP-SMX prophylaxis (adjusted OR (AOR), 30.96; 95% CI 3.63 to 264.11; p=0.002), elevated C3 levels (AOR, 35.33; 95% CI 1.33 to 936.67; p=0.033) and presence of Veillonella dispar in the vaginal microbiota (AOR, 6.68; 95% CI 1.27 to 35.07; p=0.025) were associated with UTI.Conclusions The vaginal microbiota diversity differed between patients with lupus with and without UTI, and unnecessary administration of TMP-SMX prophylaxis may affect the alpha diversity of the vaginal microbiota. |
| format | Article |
| id | doaj-art-102f4b9004e044f8afdddcbb1af8150b |
| institution | OA Journals |
| issn | 2053-8790 |
| language | English |
| publishDate | 2021-04-01 |
| publisher | BMJ Publishing Group |
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| series | Lupus Science and Medicine |
| spelling | doaj-art-102f4b9004e044f8afdddcbb1af8150b2025-08-20T02:36:23ZengBMJ Publishing GroupLupus Science and Medicine2053-87902021-04-018110.1136/lupus-2021-000551Vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus: a pilot cross-sectional study from ThailandPrapaporn Pisitkun0Pintip Ngamjanyaporn1Porpon Rotjanapan2Aunyakant Jaroensukrungruang3Jittima Manonai4Vorthon Sawaswong5Prangwalai Chanchaem6Sunchai Payungporn7Division of Allergy, Immunology and Rheumatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand1Faculty of Medicine Ramathibodi Hospital, Mahidol University, ThailandDivision of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Infectious Diseases, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandDivision of Reproductive Health and Family Planning, Department of Obstetrics and Gynecology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, ThailandProgram in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok, ThailandResearch Unit of Systems Microbiology, Department of Biochemistry, Chulalongkorn University, Bangkok, ThailandResearch Unit of Systems Microbiology, Department of Biochemistry, Chulalongkorn University, Bangkok, ThailandObjective The risk factors associated with urinary tract infections (UTIs) in patients with SLE remain uncertain. We evaluated the vaginal microbiota pattern and its potential UTI-associated risk factors.Methods A pilot cross-sectional study of patients with SLE was conducted at Ramathibodi Hospital, Bangkok, Thailand, during 2019–2020. Patients’ demographic data and relevant information were collected. Vaginal microbiota was assessed in all patients and in 10 healthy volunteers.Results Fifty-two patients were enrolled (mean age: 46.1 years). All patients had SLE that was in low disease activity. As per the Simpson_e index, the within-group alpha diversity of the vaginal microbiota was low in the SLE with UTI and SLE receiving trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis groups. Multivariate logistic regression analysis revealed that TMP-SMX prophylaxis (adjusted OR (AOR), 30.96; 95% CI 3.63 to 264.11; p=0.002), elevated C3 levels (AOR, 35.33; 95% CI 1.33 to 936.67; p=0.033) and presence of Veillonella dispar in the vaginal microbiota (AOR, 6.68; 95% CI 1.27 to 35.07; p=0.025) were associated with UTI.Conclusions The vaginal microbiota diversity differed between patients with lupus with and without UTI, and unnecessary administration of TMP-SMX prophylaxis may affect the alpha diversity of the vaginal microbiota.https://lupus.bmj.com/content/8/1/e000551.full |
| spellingShingle | Prapaporn Pisitkun Pintip Ngamjanyaporn Porpon Rotjanapan Aunyakant Jaroensukrungruang Jittima Manonai Vorthon Sawaswong Prangwalai Chanchaem Sunchai Payungporn Vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus: a pilot cross-sectional study from Thailand Lupus Science and Medicine |
| title | Vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus: a pilot cross-sectional study from Thailand |
| title_full | Vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus: a pilot cross-sectional study from Thailand |
| title_fullStr | Vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus: a pilot cross-sectional study from Thailand |
| title_full_unstemmed | Vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus: a pilot cross-sectional study from Thailand |
| title_short | Vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus: a pilot cross-sectional study from Thailand |
| title_sort | vaginal microbiota affects urinary tract infection risk in women with systemic lupus erythematosus a pilot cross sectional study from thailand |
| url | https://lupus.bmj.com/content/8/1/e000551.full |
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