Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster
Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-01-01
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| Series: | Emerging Microbes and Infections |
| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2020.1752610 |
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| _version_ | 1850200372837089280 |
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| author | Yan Xu Meng Xiao Xinchao Liu Shengyong Xu Tiekuan Du Jun Xu Qiwen Yang Yingchun Xu Yang Han Taisheng Li Huadong Zhu Mengzhao Wang |
| author_facet | Yan Xu Meng Xiao Xinchao Liu Shengyong Xu Tiekuan Du Jun Xu Qiwen Yang Yingchun Xu Yang Han Taisheng Li Huadong Zhu Mengzhao Wang |
| author_sort | Yan Xu |
| collection | DOAJ |
| description | Confirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular assays only detected two of this five patients even repeated twice. We comprehensively analyzed this familial cluster of cases based on the clinical characteristics, chest CT images, SARS-CoV-2 molecular detection results, and serology testing results. At last, two patients were diagnosed with COVID-19, two were suspected of COVID-19, and two were considered close contacts. Our results emphasized the significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections, especially for COVID-19 close contacts screening. |
| format | Article |
| id | doaj-art-102ea9ce1988460e90a95b7aa443255e |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-102ea9ce1988460e90a95b7aa443255e2025-08-20T02:12:20ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512020-01-019192492710.1080/22221751.2020.1752610Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family clusterYan Xu0Meng Xiao1Xinchao Liu2Shengyong Xu3Tiekuan Du4Jun Xu5Qiwen Yang6Yingchun Xu7Yang Han8Taisheng Li9Huadong Zhu10Mengzhao Wang11Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaPeking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of ChinaConfirmative diagnosis of SARS-CoV-2 infections has been challenged due to unsatisfactory positive rate of molecular assays. Here we identified a family cluster of SARS-CoV-2 infections, with five of six family members were SARS-CoV-2-specific immunoglobin serology testing positive, while molecular assays only detected two of this five patients even repeated twice. We comprehensively analyzed this familial cluster of cases based on the clinical characteristics, chest CT images, SARS-CoV-2 molecular detection results, and serology testing results. At last, two patients were diagnosed with COVID-19, two were suspected of COVID-19, and two were considered close contacts. Our results emphasized the significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections, especially for COVID-19 close contacts screening.https://www.tandfonline.com/doi/10.1080/22221751.2020.1752610 |
| spellingShingle | Yan Xu Meng Xiao Xinchao Liu Shengyong Xu Tiekuan Du Jun Xu Qiwen Yang Yingchun Xu Yang Han Taisheng Li Huadong Zhu Mengzhao Wang Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster Emerging Microbes and Infections |
| title | Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster |
| title_full | Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster |
| title_fullStr | Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster |
| title_full_unstemmed | Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster |
| title_short | Significance of serology testing to assist timely diagnosis of SARS-CoV-2 infections: implication from a family cluster |
| title_sort | significance of serology testing to assist timely diagnosis of sars cov 2 infections implication from a family cluster |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2020.1752610 |
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