Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia
The new coronavirus infection (COVID-19) is associated with a wide spectrum of various clinical manifestations including involvement of the musculoskeletal system which can persist for a long time after the infection. Supposedly, pathogenesis of musculoskeletal manifestations of COVID-19 is primaril...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2022-03-01
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| Series: | Klinicist |
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| Online Access: | https://klinitsist.abvpress.ru/Klin/article/view/472 |
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| author | N. A. Shostak A. A. Klimenko N. A. Demidova A. A. Kondrashov D. Yu. Andryashkina Yu. M. Saakyan G. A. Varaksin A. Yu. Tarantina |
| author_facet | N. A. Shostak A. A. Klimenko N. A. Demidova A. A. Kondrashov D. Yu. Andryashkina Yu. M. Saakyan G. A. Varaksin A. Yu. Tarantina |
| author_sort | N. A. Shostak |
| collection | DOAJ |
| description | The new coronavirus infection (COVID-19) is associated with a wide spectrum of various clinical manifestations including involvement of the musculoskeletal system which can persist for a long time after the infection. Supposedly, pathogenesis of musculoskeletal manifestations of COVID-19 is primarily caused by systemic inflammation accompanied by cytokine hyperexpression (interferon γ, interleukins 1β, 6, 8, 17, tumor necrosis factor α), as well as hypoxia leading to overproduction of inflammatory cytokines, activation of bone reabsorption by osteoclasts and subsequent decrease of mineral bone density and osteonecrosis in some cases. Additionally, some drugs prescribed to patients with COVID-19 (some antiviral drugs and glucocorticoids) should also be taken into account as they can lead to development of musculoskeletal pathology. In the acute period of COVID-19, myalgias are common, but in rare cases myositis with proximal muscular weakness and increased levels of creatine phosphokinase, lactate dehydrogenase can occur. Arthralgias in the acute period of COVID-19 are rarer than myalgias. In the studies of clinical manifestation of COVID-19, frequency of arthralgias and myalgias in the acute period is between 15.5 and 50 %. After COVID-19, frequency of arthralgias and myalgias gradually decreases, however there are cases of long-term joint and muscle pains, as well as post-viral arthritis, development of arthritis in the context of various autoimmune disorders. Myalgias and arthralgias during COVID-19 usually regress spontaneously and in most patients do not require prescription of antipain medications, but in some cases pain management is necessary. Use of non-steroid anti-inflammatory drugs and vitamin D during COVID-19 is a safe and effective method of pain management, including myalgia and arthralgia. Rehabilitation programs play an important role in improvement of functional state and patient recovery after moderate and severe COVID-19. |
| format | Article |
| id | doaj-art-102d87c20cd94009b2ba95ead34c3387 |
| institution | Kabale University |
| issn | 1818-8338 |
| language | Russian |
| publishDate | 2022-03-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Klinicist |
| spelling | doaj-art-102d87c20cd94009b2ba95ead34c33872025-08-20T04:00:43ZrusABV-pressKlinicist1818-83382022-03-01151-4314110.17650/1818-8338-2021-15-1-4-K650363Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgiaN. A. Shostak0A. A. Klimenko1N. A. Demidova2A. A. Kondrashov3D. Yu. Andryashkina4Yu. M. Saakyan5G. A. Varaksin6A. Yu. Tarantina7Pirogov Russian National Research Medical University, Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of RussiaPirogov Russian National Research Medical University, Ministry of Health of RussiaThe new coronavirus infection (COVID-19) is associated with a wide spectrum of various clinical manifestations including involvement of the musculoskeletal system which can persist for a long time after the infection. Supposedly, pathogenesis of musculoskeletal manifestations of COVID-19 is primarily caused by systemic inflammation accompanied by cytokine hyperexpression (interferon γ, interleukins 1β, 6, 8, 17, tumor necrosis factor α), as well as hypoxia leading to overproduction of inflammatory cytokines, activation of bone reabsorption by osteoclasts and subsequent decrease of mineral bone density and osteonecrosis in some cases. Additionally, some drugs prescribed to patients with COVID-19 (some antiviral drugs and glucocorticoids) should also be taken into account as they can lead to development of musculoskeletal pathology. In the acute period of COVID-19, myalgias are common, but in rare cases myositis with proximal muscular weakness and increased levels of creatine phosphokinase, lactate dehydrogenase can occur. Arthralgias in the acute period of COVID-19 are rarer than myalgias. In the studies of clinical manifestation of COVID-19, frequency of arthralgias and myalgias in the acute period is between 15.5 and 50 %. After COVID-19, frequency of arthralgias and myalgias gradually decreases, however there are cases of long-term joint and muscle pains, as well as post-viral arthritis, development of arthritis in the context of various autoimmune disorders. Myalgias and arthralgias during COVID-19 usually regress spontaneously and in most patients do not require prescription of antipain medications, but in some cases pain management is necessary. Use of non-steroid anti-inflammatory drugs and vitamin D during COVID-19 is a safe and effective method of pain management, including myalgia and arthralgia. Rehabilitation programs play an important role in improvement of functional state and patient recovery after moderate and severe COVID-19.https://klinitsist.abvpress.ru/Klin/article/view/472covid-19coronavirus infectionmusculoskeletal manifestationsarthralgiamyalgiaosteonecrosistoxic myopathypain syndromepost-covid syndromelong-term covid-19non-steroid anti-inflammatory drugsvitamin dsysadoaalflutop |
| spellingShingle | N. A. Shostak A. A. Klimenko N. A. Demidova A. A. Kondrashov D. Yu. Andryashkina Yu. M. Saakyan G. A. Varaksin A. Yu. Tarantina Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia Klinicist covid-19 coronavirus infection musculoskeletal manifestations arthralgia myalgia osteonecrosis toxic myopathy pain syndrome post-covid syndrome long-term covid-19 non-steroid anti-inflammatory drugs vitamin d sysadoa alflutop |
| title | Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia |
| title_full | Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia |
| title_fullStr | Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia |
| title_full_unstemmed | Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia |
| title_short | Musculoskeletal manifectations of the new coronavirus infection: focus on arthralgia and myalgia |
| title_sort | musculoskeletal manifectations of the new coronavirus infection focus on arthralgia and myalgia |
| topic | covid-19 coronavirus infection musculoskeletal manifestations arthralgia myalgia osteonecrosis toxic myopathy pain syndrome post-covid syndrome long-term covid-19 non-steroid anti-inflammatory drugs vitamin d sysadoa alflutop |
| url | https://klinitsist.abvpress.ru/Klin/article/view/472 |
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