Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis
The objective: to investigate the relationship of polymorphic variants of genes of xenobiotic biotransformation metabolism enzymes (NAT2 (590G>A (rs1799930)), CYP2E1 (9896C>G (rs2070676)), ABCB1 (3435T>C (rs1045642)), GSTM1 (E/D), GSTT1 (E/D) with the risk of pulmonary tuberculo...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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New Terra Publishing House
2022-07-01
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| Series: | Туберкулез и болезни лёгких |
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| Online Access: | https://www.tibl-journal.com/jour/article/view/1646 |
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| author | M. A. Alymenko R. Sh. Valiev A. V. Polonikov T. N. Golubeva A. P. Vasilevskaya E. V. Miroshnik |
| author_facet | M. A. Alymenko R. Sh. Valiev A. V. Polonikov T. N. Golubeva A. P. Vasilevskaya E. V. Miroshnik |
| author_sort | M. A. Alymenko |
| collection | DOAJ |
| description | The objective: to investigate the relationship of polymorphic variants of genes of xenobiotic biotransformation metabolism enzymes (NAT2 (590G>A (rs1799930)), CYP2E1 (9896C>G (rs2070676)), ABCB1 (3435T>C (rs1045642)), GSTM1 (E/D), GSTT1 (E/D) with the risk of pulmonary tuberculosis.Subjects and Methods. Within the framework of this study, a population sample of unrelated 1081 individuals of Slavic nationalities (mainly Russians) living in the territory of Kursk Oblast was used.Results. The del/del (D/D) GSTM1 genotype was associated with an increased risk of developing tuberculosis, while carrying the del/del (D/D) GSTT1 genotype was associated with a lower risk of developing the disease. Polymorphism 3435T>C ABCB1 (TC genotype) was associated with increased susceptibility to pulmonary tuberculosis in the codominization model, while TT+TC genotypes had the same association in the dominance model. |
| format | Article |
| id | doaj-art-102d22a1a4ce42cfb1a24ea962fd1fc3 |
| institution | OA Journals |
| issn | 2075-1230 2542-1506 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | New Terra Publishing House |
| record_format | Article |
| series | Туберкулез и болезни лёгких |
| spelling | doaj-art-102d22a1a4ce42cfb1a24ea962fd1fc32025-08-20T02:16:01ZrusNew Terra Publishing HouseТуберкулез и болезни лёгких2075-12302542-15062022-07-011006172410.21292/2075-1230-2022-100-6-17-221641Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosisM. A. Alymenko0R. Sh. Valiev1A. V. Polonikov2T. N. Golubeva3A. P. Vasilevskaya4E. V. Miroshnik5Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education; Kursk Regional Health CommitteeKazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional EducationResearch Institute of Genetic and Molecular Epidemiology, Kursk State Medical UniversityRegional Clinical TB DispensaryRegional Clinical TB DispensaryKursk Regional Health CommitteeThe objective: to investigate the relationship of polymorphic variants of genes of xenobiotic biotransformation metabolism enzymes (NAT2 (590G>A (rs1799930)), CYP2E1 (9896C>G (rs2070676)), ABCB1 (3435T>C (rs1045642)), GSTM1 (E/D), GSTT1 (E/D) with the risk of pulmonary tuberculosis.Subjects and Methods. Within the framework of this study, a population sample of unrelated 1081 individuals of Slavic nationalities (mainly Russians) living in the territory of Kursk Oblast was used.Results. The del/del (D/D) GSTM1 genotype was associated with an increased risk of developing tuberculosis, while carrying the del/del (D/D) GSTT1 genotype was associated with a lower risk of developing the disease. Polymorphism 3435T>C ABCB1 (TC genotype) was associated with increased susceptibility to pulmonary tuberculosis in the codominization model, while TT+TC genotypes had the same association in the dominance model.https://www.tibl-journal.com/jour/article/view/1646pulmonary tuberculosisxenobiotic biotransformation enzymesgene allelic polymorphismgenetic susceptibility to pulmonary tuberculosis |
| spellingShingle | M. A. Alymenko R. Sh. Valiev A. V. Polonikov T. N. Golubeva A. P. Vasilevskaya E. V. Miroshnik Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis Туберкулез и болезни лёгких pulmonary tuberculosis xenobiotic biotransformation enzymes gene allelic polymorphism genetic susceptibility to pulmonary tuberculosis |
| title | Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis |
| title_full | Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis |
| title_fullStr | Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis |
| title_full_unstemmed | Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis |
| title_short | Association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis |
| title_sort | association of polymorphic gene variants of xenobiotic biotransformation enzymes with susceptibility to pulmonary tuberculosis |
| topic | pulmonary tuberculosis xenobiotic biotransformation enzymes gene allelic polymorphism genetic susceptibility to pulmonary tuberculosis |
| url | https://www.tibl-journal.com/jour/article/view/1646 |
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