Alpha-linolenic acid protects against heatstroke-induced acute lung injury by inhibiting ferroptosis through Nrf2 activation

Alpha-linolenic acid protects against heatstroke-induced acute lung injury by inhibiting ferroptosis through Nrf2 activation

Heatstroke (HS)-induced acute lung injury (ALI) has high morbidity and mortality with no specific therapies. Ferroptosis, a form of programmed cell death driven by lipid peroxidation due to reduced Glutathione Peroxidase 4 (GPX4) activity, is closely linked to HS-induced ALI. This study investigated...

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Bibliographic Details
Main Authors: Lin Wang, Jiamin Ma, Zhaozheng Li, Xinru Zhao, Ying Chen, Pei Wang, Yi Li, Yuwei Chen, Xuanqi Yao, Liangfang Yao, Jinbao Li
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Redox Report
Subjects:
Heatstroke
alpha-linolenic acid
Nrf2
ferroptosis
acute lung injury
SLC7A11
Online Access:https://www.tandfonline.com/doi/10.1080/13510002.2025.2538294
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