EZH1 deficiency promotes ferroptosis resistance by activating NRF2 in sepsis-associated liver injury

EZH1 deficiency promotes ferroptosis resistance by activating NRF2 in sepsis-associated liver injury

Abstract Sepsis-associated acute liver injury (SALI) is a major clinical complication of sepsis due to excessive, unfettered inflammation. In recent years, the role of epigenetic regulatory mechanisms in SALI has been gradually emphasized. Here, we investigated the effects of a Histone-lysine N-meth...

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Bibliographic Details
Main Authors: Meihua Mei, Ying You, Ningxin Tan, Xiaoshun He, Junqi Huang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Clinical Epigenetics
Subjects:
Sepsis
Liver injury
EZH1
Ferroptosis
NRF2
Online Access:https://doi.org/10.1186/s13148-025-01892-2
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