Global estimation of dengue disability weights based on clinical manifestations data
Abstract Background Dengue is a major global health threat with varied clinical manifestations across age groups, countries, and regions. This study aims to estimate global dengue disability weights (DWs) based on clinical manifestations data and examine variations across different demographics and...
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BMC
2025-06-01
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| Series: | Infectious Diseases of Poverty |
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| Online Access: | https://doi.org/10.1186/s40249-025-01317-5 |
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| author | Han-Qi Ouyang Zi-Yu Zhao Okugbe Ebiotubo Ohore Wei-Hao Li Li Hong Li-Ying Wang Hong-Rui Zhang Fu-Chun Zhang Raman Velayudhan Daniel Argaw Dagne Ibrahima Socé Fall Guo-Jing Yang |
| author_facet | Han-Qi Ouyang Zi-Yu Zhao Okugbe Ebiotubo Ohore Wei-Hao Li Li Hong Li-Ying Wang Hong-Rui Zhang Fu-Chun Zhang Raman Velayudhan Daniel Argaw Dagne Ibrahima Socé Fall Guo-Jing Yang |
| author_sort | Han-Qi Ouyang |
| collection | DOAJ |
| description | Abstract Background Dengue is a major global health threat with varied clinical manifestations across age groups, countries, and regions. This study aims to estimate global dengue disability weights (DWs) based on clinical manifestations data and examine variations across different demographics and geographical areas. These findings will inform public health strategies and interventions to reduce the global burden of dengue. Methods We conducted a systematic search across six databases (Scopus, Web of Science, PubMed, China National Knowledge Infrastructure, Wanfang Data, and Database of Chinese sci-tech periodicals) for studies on human dengue clinical manifestations or infection from the establishment of each database through December 31, 2023. DWs were estimated by combining clinical manifestations frequencies with corresponding DW values derived from the Global Burden of Disease (GBD) study, using Monte Carlo simulations to generate uncertainty intervals. Odds ratios (ORs) with 95% confidence intervals (CI) and Chi-square tests were performed to compare clinical manifestations between adults and children. Results A total of 35 adult studies (7109 cases) and 17 pediatric studies (2996 cases) were analysed. Adults had higher rates of muscle pain (OR = 9.18; 95% CI: 8.17–10.33) and weak (OR = 4.95; 95% CI 4.12–5.98). Children showed higher frequencies of decreased appetite (OR = 0.12; 95% CI: 0.11–0.14) and lymphadenectasis (OR = 0.04; 95% CI: 0.03–0.06). Severe dengue was more prevalent in children (8.2%) than adults (4.6%). The global DW for universal dengue was 0.3258 in adults and 0.4022 in children, with Indian children showing the highest DW for severe dengue (0.6991) and Chinese adult showing the highest DW for severe dengue (0.7214). Regionally, most studies were from South and Southeast Asia, with India contributing the largest number of publications (80 articles). Additionally, India had the highest dengue disease burden in 2021 (352,468.54 person-years). Conclusions These findings reveal important age and regional differences in dengue disease burden. There is a relative lack of research on dengue clinical manifestations in several high-burden countries in the Americas, and these gaps may affect the comprehensiveness and accuracy of global dengue disability weight estimates. These highlight the urgent need for targeted interventions and optimized resource allocation to mitigate its global impact. Graphical Abstract |
| format | Article |
| id | doaj-art-10253a1b3ce541a2b880b753aa28cf6e |
| institution | DOAJ |
| issn | 2049-9957 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
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| series | Infectious Diseases of Poverty |
| spelling | doaj-art-10253a1b3ce541a2b880b753aa28cf6e2025-08-20T02:39:48ZengBMCInfectious Diseases of Poverty2049-99572025-06-0114111210.1186/s40249-025-01317-5Global estimation of dengue disability weights based on clinical manifestations dataHan-Qi Ouyang0Zi-Yu Zhao1Okugbe Ebiotubo Ohore2Wei-Hao Li3Li Hong4Li-Ying Wang5Hong-Rui Zhang6Fu-Chun Zhang7Raman Velayudhan8Daniel Argaw Dagne9Ibrahima Socé Fall10Guo-Jing Yang11School of Public Health, Hainan Medical University (Hainan Academy of Medical Sciences)School of Public Health, Hainan Medical University (Hainan Academy of Medical Sciences)NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University (Hainan Academy of Medical Sciences)School of Public Health, Hainan Medical University (Hainan Academy of Medical Sciences)School of Public Health, Hainan Medical University (Hainan Academy of Medical Sciences)NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University (Hainan Academy of Medical Sciences)NHC Key Laboratory of Tropical Disease Control, School of Tropical Medicine, Hainan Medical University (Hainan Academy of Medical Sciences)Guangzhou Medical Research Institute of Infectious Diseases, Infectious Disease Center, Guangzhou Eighth People’s Hospital, Guangzhou Medical UniversityDepartment of Control of Neglected Tropical Diseases, World Health OrganizationDepartment of Control of Neglected Tropical Diseases, World Health OrganizationDepartment of Control of Neglected Tropical Diseases, World Health OrganizationSchool of Public Health, Hainan Medical University (Hainan Academy of Medical Sciences)Abstract Background Dengue is a major global health threat with varied clinical manifestations across age groups, countries, and regions. This study aims to estimate global dengue disability weights (DWs) based on clinical manifestations data and examine variations across different demographics and geographical areas. These findings will inform public health strategies and interventions to reduce the global burden of dengue. Methods We conducted a systematic search across six databases (Scopus, Web of Science, PubMed, China National Knowledge Infrastructure, Wanfang Data, and Database of Chinese sci-tech periodicals) for studies on human dengue clinical manifestations or infection from the establishment of each database through December 31, 2023. DWs were estimated by combining clinical manifestations frequencies with corresponding DW values derived from the Global Burden of Disease (GBD) study, using Monte Carlo simulations to generate uncertainty intervals. Odds ratios (ORs) with 95% confidence intervals (CI) and Chi-square tests were performed to compare clinical manifestations between adults and children. Results A total of 35 adult studies (7109 cases) and 17 pediatric studies (2996 cases) were analysed. Adults had higher rates of muscle pain (OR = 9.18; 95% CI: 8.17–10.33) and weak (OR = 4.95; 95% CI 4.12–5.98). Children showed higher frequencies of decreased appetite (OR = 0.12; 95% CI: 0.11–0.14) and lymphadenectasis (OR = 0.04; 95% CI: 0.03–0.06). Severe dengue was more prevalent in children (8.2%) than adults (4.6%). The global DW for universal dengue was 0.3258 in adults and 0.4022 in children, with Indian children showing the highest DW for severe dengue (0.6991) and Chinese adult showing the highest DW for severe dengue (0.7214). Regionally, most studies were from South and Southeast Asia, with India contributing the largest number of publications (80 articles). Additionally, India had the highest dengue disease burden in 2021 (352,468.54 person-years). Conclusions These findings reveal important age and regional differences in dengue disease burden. There is a relative lack of research on dengue clinical manifestations in several high-burden countries in the Americas, and these gaps may affect the comprehensiveness and accuracy of global dengue disability weight estimates. These highlight the urgent need for targeted interventions and optimized resource allocation to mitigate its global impact. Graphical Abstracthttps://doi.org/10.1186/s40249-025-01317-5DengueClinical manifestationDisability weightMeta-analysisRegion-specific |
| spellingShingle | Han-Qi Ouyang Zi-Yu Zhao Okugbe Ebiotubo Ohore Wei-Hao Li Li Hong Li-Ying Wang Hong-Rui Zhang Fu-Chun Zhang Raman Velayudhan Daniel Argaw Dagne Ibrahima Socé Fall Guo-Jing Yang Global estimation of dengue disability weights based on clinical manifestations data Infectious Diseases of Poverty Dengue Clinical manifestation Disability weight Meta-analysis Region-specific |
| title | Global estimation of dengue disability weights based on clinical manifestations data |
| title_full | Global estimation of dengue disability weights based on clinical manifestations data |
| title_fullStr | Global estimation of dengue disability weights based on clinical manifestations data |
| title_full_unstemmed | Global estimation of dengue disability weights based on clinical manifestations data |
| title_short | Global estimation of dengue disability weights based on clinical manifestations data |
| title_sort | global estimation of dengue disability weights based on clinical manifestations data |
| topic | Dengue Clinical manifestation Disability weight Meta-analysis Region-specific |
| url | https://doi.org/10.1186/s40249-025-01317-5 |
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