Comparative efficacy Shengxuening and polysaccharide iron complex treatment of anemia in patients with peritoneal dialysis
Objective To observe the effect of Shengxuening tablets and polysaccharide iron complex with erythropoietin（EPO） treatment of anemia in peritoneal dialysis patients.Methods 50 patients with continuous ambulatory peritoneal dialysis（CAPD） patients were randomly divided into two groups,each group of 2...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
| Subjects: | |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57919704&Fpath=home&index=0 |
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| Summary: | Objective To observe the effect of Shengxuening tablets and polysaccharide iron complex with erythropoietin（EPO） treatment of anemia in peritoneal dialysis patients.Methods 50 patients with continuous ambulatory peritoneal dialysis（CAPD） patients were randomly divided into two groups,each group of 25 cases.Shengxuening tablet group was treated with Shengxuening tablets（0.5 g,three times a day）,polysaccharide iron complex group was treated with polysaccharide iron complex（0.15 g,Once daily）,were observed 12 weeks.The anemia of the two groups was effectively corrected after treatment The initial dosage of EPO was 100<sup>1</sup>50 IU·kg<sup>-1</sup>·W<sup>-1</sup>.Red blood cell specific volume（Hct） was test every two weeks after injection,if Hct increased by 4%,reduce dose by25%.After Hct reached 30%,the dosage of EPO was reduced to 75 IU·kg<sup>-1</sup>·W<sup>-1</sup>.The medication is continue to maintain,Hct level will be remained at about 35%.Results Before the treatment,there were no significant differences in levels of hemoglobin,red blood cell specific volume and transferrin saturation between the two groups（P>0.05）.The anemia of the two groups was effectively corrected after treatment.There was no significant difference between the two groups（P>0.05）.The two groups of patients with a dose of EPO after treatment were decreased.The general adverse reactions and nausea of the shengxuening tablet group were lower than the polysaccharide iron complex group.Conclusions The effect of anemia in patients with peritoneal dialysis between Shengxuening and Polysaccharide iron complex are same,and can reduce the amount of EPO.Shengxuening sheet can effectively correct anemia and improve iron utilization efficiency,improve iron metabolism,and can improve the efficacy of EPO and enhance the EPO cost-effectiveness and reduce the amount of EPO to maintain,reduce the financial burden of patients. |
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| ISSN: | 1671-2390 |