Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden of disease study
IntroductionCongenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.MethodsThis study utilized the Global Burden of Disease (GBD) database to examine trends in CHD-related mortality a...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-07-01
|
| Series: | Frontiers in Public Health |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1537671/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849428842491412480 |
|---|---|
| author | Jiaoli Xu Qinhong Li Jingxuan Xiong Zugen Cheng Lili Deng |
| author_facet | Jiaoli Xu Qinhong Li Jingxuan Xiong Zugen Cheng Lili Deng |
| author_sort | Jiaoli Xu |
| collection | DOAJ |
| description | IntroductionCongenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.MethodsThis study utilized the Global Burden of Disease (GBD) database to examine trends in CHD-related mortality among children aged 0-14 from 1990 to 2021.ResultsWe report a 55.34% reduction in CHD-related deaths among children, with global mortality rates decreasing from 28.63 per 100,000 in 1990 to 11.06 per 100,000 in 2021. Notably, the decline in mortality was more pronounced in younger children, with the highest burden observed in the Low socio-demographic index (SDI) region, where CHD-related mortality rates remain disproportionately high. In contrast, the high SDI region experienced the greatest improvements in mortality reduction. Regional disparities are also evident, with South Asia bearing the highest number of CHD-related deaths, while Oceania exhibited the highest mortality rate.DiscussionThese trends underscore the need for continued global efforts to reduce CHD-related mortality, particularly in low-income regions, and to address the disparities in healthcare access and outcomes. Our findings highlight the ongoing challenges in pediatric cardiology and the need for targeted interventions to sustain improvements in CHD survival, especially for neonates and infants. |
| format | Article |
| id | doaj-art-101a535394054a2d8f535ab4a6f4fdf2 |
| institution | Kabale University |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj-art-101a535394054a2d8f535ab4a6f4fdf22025-08-20T03:28:33ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-07-011310.3389/fpubh.2025.15376711537671Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden of disease studyJiaoli Xu0Qinhong Li1Jingxuan Xiong2Zugen Cheng3Lili Deng4Department of Cardiology, Kunming Children's Hospital, Kunming, ChinaDepartment of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, ChinaDepartment of Respiratory Medicine, Kunming Children's Hospital, Kunming, Yunnan, ChinaDepartment of Cardiology, Kunming Children's Hospital, Kunming, ChinaDepartment of Cardiology, Kunming Children's Hospital, Kunming, ChinaIntroductionCongenital heart disease (CHD) represents a significant global public health burden, with substantial variability in mortality rates across different regions and age groups.MethodsThis study utilized the Global Burden of Disease (GBD) database to examine trends in CHD-related mortality among children aged 0-14 from 1990 to 2021.ResultsWe report a 55.34% reduction in CHD-related deaths among children, with global mortality rates decreasing from 28.63 per 100,000 in 1990 to 11.06 per 100,000 in 2021. Notably, the decline in mortality was more pronounced in younger children, with the highest burden observed in the Low socio-demographic index (SDI) region, where CHD-related mortality rates remain disproportionately high. In contrast, the high SDI region experienced the greatest improvements in mortality reduction. Regional disparities are also evident, with South Asia bearing the highest number of CHD-related deaths, while Oceania exhibited the highest mortality rate.DiscussionThese trends underscore the need for continued global efforts to reduce CHD-related mortality, particularly in low-income regions, and to address the disparities in healthcare access and outcomes. Our findings highlight the ongoing challenges in pediatric cardiology and the need for targeted interventions to sustain improvements in CHD survival, especially for neonates and infants.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1537671/fullmortalitychildhoodcongenital heart disease (CHD)public healthGBD (global burden disease) |
| spellingShingle | Jiaoli Xu Qinhong Li Jingxuan Xiong Zugen Cheng Lili Deng Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden of disease study Frontiers in Public Health mortality childhood congenital heart disease (CHD) public health GBD (global burden disease) |
| title | Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden of disease study |
| title_full | Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden of disease study |
| title_fullStr | Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden of disease study |
| title_full_unstemmed | Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden of disease study |
| title_short | Time trends in mortality of congenital heart disease in children aged 0–14 years: a global, regional, and national cohort analysis from 1990 to 2021 using the global burden of disease study |
| title_sort | time trends in mortality of congenital heart disease in children aged 0 14 years a global regional and national cohort analysis from 1990 to 2021 using the global burden of disease study |
| topic | mortality childhood congenital heart disease (CHD) public health GBD (global burden disease) |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1537671/full |
| work_keys_str_mv | AT jiaolixu timetrendsinmortalityofcongenitalheartdiseaseinchildrenaged014yearsaglobalregionalandnationalcohortanalysisfrom1990to2021usingtheglobalburdenofdiseasestudy AT qinhongli timetrendsinmortalityofcongenitalheartdiseaseinchildrenaged014yearsaglobalregionalandnationalcohortanalysisfrom1990to2021usingtheglobalburdenofdiseasestudy AT jingxuanxiong timetrendsinmortalityofcongenitalheartdiseaseinchildrenaged014yearsaglobalregionalandnationalcohortanalysisfrom1990to2021usingtheglobalburdenofdiseasestudy AT zugencheng timetrendsinmortalityofcongenitalheartdiseaseinchildrenaged014yearsaglobalregionalandnationalcohortanalysisfrom1990to2021usingtheglobalburdenofdiseasestudy AT lilideng timetrendsinmortalityofcongenitalheartdiseaseinchildrenaged014yearsaglobalregionalandnationalcohortanalysisfrom1990to2021usingtheglobalburdenofdiseasestudy |