Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages

Physiologically based pharmacokinetic modeling supports investigation of potential drug-drug interactions in the pre- and early post-hematopoietic stem cell transplantation stages

IntroductionDrug-drug interactions (DDIs) are an important issue in medication safety and a potential cause of adverse drug events in the pre- and early post-hematopoietic stem cell transplantation (HSCT). This study introduced a physiologically based pharmacokinetic (PBPK) modeling platform to eval...

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Bibliographic Details
Main Authors: Peile Wang, Jingli Lu, Jing Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
HSCT
PBPK modeling
DDIs
pharmacokinetics
personalized dosing
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1578643/full
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