Timbe (<i>Acaciella angustissima</i>) as an Alternative Source of Compounds with Biological Activity: Antidiabetic

Timbe (<i>Acaciella angustissima</i>) as an Alternative Source of Compounds with Biological Activity: Antidiabetic

<b>Background/Objectives:</b> Timbe (<i>Acaciella angustissima</i>) is a legume recognized for its environmental benefits, such as soil restoration, wildlife nutrition, and the presence of biologically active compounds. This study investigates the antioxidant, pharmacological...

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Main Authors: Diana Karina Rangel-Sandoval, Lucia Guerrero-Becerra, Consuelo Lomas-Soria, Amanda Kim Rico-Chávez, José Antonio Cervantes-Chávez, Luis Antonio Reyes-Castro, Angélica Morales-Miranda, Ana Angélica Feregrino-Pérez
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceuticals
Subjects:
antimicrobial activity
antioxidant activity
diabetes mellitus
hypertensive
legume
phenolic compounds
Online Access:https://www.mdpi.com/1424-8247/18/4/593
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Summary:<b>Background/Objectives:</b> Timbe (<i>Acaciella angustissima</i>) is a legume recognized for its environmental benefits, such as soil restoration, wildlife nutrition, and the presence of biologically active compounds. This study investigates the antioxidant, pharmacological, and antimicrobial properties of Timbe. <b>Methods:</b> The total phenolic content, flavonoids, and condensed tannins from Timbe flowers, seeds, and pods were quantified, and their antioxidant activity was evaluated using the DPPH and ABTS assays. Enzymatic activities were assessed through α-amylase, α-glucosidase, and ACE-I inhibition, and antimicrobial properties were tested against various bacterial strains. <b>Results:</b> The pods and flowers exhibited higher antioxidant capacities compared to seeds, effectively neutralizing free radicals. Flavonoids and condensed tannins showed positive correlations with antioxidant activity and the inhibition of α-amylase and α-glucosidase, suggesting the potential benefits of these metabolites in blood glucose control. Timbe also demonstrated ACE-I inhibition, particularly the flowers. Regarding antimicrobial activity, the pods displayed moderate inhibition against <i>E. coli</i>, <i>K. pneumoniae</i>, and <i>S. aureus</i>. <b>Conclusions:</b> The results indicate that different parts of Timbe (flowers, seeds, and pods) possess significant therapeutic potential for preventing and treating metabolic disorders and bacterial infections.
ISSN:1424-8247

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