Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease
Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection was originally described by Erdheim as a noninflammatory lesion related to the loss of smooth muscle cells and elastic fibre fragmentation in the media. Recent evidences propose the strong role of a chronic immu...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/1274034 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832558499307978752 |
|---|---|
| author | Calogera Pisano Carmela Rita Balistreri Alessandro Ricasoli Giovanni Ruvolo |
| author_facet | Calogera Pisano Carmela Rita Balistreri Alessandro Ricasoli Giovanni Ruvolo |
| author_sort | Calogera Pisano |
| collection | DOAJ |
| description | Medial degeneration associated with thoracic aortic aneurysm and acute aortic dissection was originally described by Erdheim as a noninflammatory lesion related to the loss of smooth muscle cells and elastic fibre fragmentation in the media. Recent evidences propose the strong role of a chronic immune/inflammatory process in aneurysm evocation and progression. The coexistence of inflammatory cells with markers of apoptotic vascular cell death in the media of ascending aorta with aneurysms and type A dissections raises the possibility that activated T cells and macrophages may contribute to the elimination of smooth muscle cells and degradation of the matrix. On the other hand, several inflammatory pathways (including TGF-β, TLR-4 interferon-γ, chemokines, and interferon-γ) seem to be involved in the medial degeneration related to aged and dilated aorta. This is an overview on thoracic aortic aneurysm as an emerging inflammatory disease. |
| format | Article |
| id | doaj-art-1012e940c14a441c841772a5444c5fc7 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-1012e940c14a441c841772a5444c5fc72025-02-03T01:32:11ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/12740341274034Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory DiseaseCalogera Pisano0Carmela Rita Balistreri1Alessandro Ricasoli2Giovanni Ruvolo3Cardiac Surgery Unit, “P. Giaccone” University Hospital, Palermo, ItalyDepartment of Pathobiology and Medical and Forensic Biotechnologies, University of Palermo, Palermo, ItalyCardiac Surgery Unit, “P. Giaccone” University Hospital, Palermo, ItalyCardiac Surgery Unit, Tor Vergata University Hospital, Rome, ItalyMedial degeneration associated with thoracic aortic aneurysm and acute aortic dissection was originally described by Erdheim as a noninflammatory lesion related to the loss of smooth muscle cells and elastic fibre fragmentation in the media. Recent evidences propose the strong role of a chronic immune/inflammatory process in aneurysm evocation and progression. The coexistence of inflammatory cells with markers of apoptotic vascular cell death in the media of ascending aorta with aneurysms and type A dissections raises the possibility that activated T cells and macrophages may contribute to the elimination of smooth muscle cells and degradation of the matrix. On the other hand, several inflammatory pathways (including TGF-β, TLR-4 interferon-γ, chemokines, and interferon-γ) seem to be involved in the medial degeneration related to aged and dilated aorta. This is an overview on thoracic aortic aneurysm as an emerging inflammatory disease.http://dx.doi.org/10.1155/2017/1274034 |
| spellingShingle | Calogera Pisano Carmela Rita Balistreri Alessandro Ricasoli Giovanni Ruvolo Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease Mediators of Inflammation |
| title | Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease |
| title_full | Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease |
| title_fullStr | Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease |
| title_full_unstemmed | Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease |
| title_short | Cardiovascular Disease in Ageing: An Overview on Thoracic Aortic Aneurysm as an Emerging Inflammatory Disease |
| title_sort | cardiovascular disease in ageing an overview on thoracic aortic aneurysm as an emerging inflammatory disease |
| url | http://dx.doi.org/10.1155/2017/1274034 |
| work_keys_str_mv | AT calogerapisano cardiovasculardiseaseinageinganoverviewonthoracicaorticaneurysmasanemerginginflammatorydisease AT carmelaritabalistreri cardiovasculardiseaseinageinganoverviewonthoracicaorticaneurysmasanemerginginflammatorydisease AT alessandroricasoli cardiovasculardiseaseinageinganoverviewonthoracicaorticaneurysmasanemerginginflammatorydisease AT giovanniruvolo cardiovasculardiseaseinageinganoverviewonthoracicaorticaneurysmasanemerginginflammatorydisease |