Salusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases
Human salusin-α and salusin-β are related peptides produced from prosalusin. Bolus injection of salusin-β into rats induces more profound hypotension and bradycardia than salusin-α. Central administration of salusin-β increases blood pressure via release of norepinephrine and arginine-vasopressin. C...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2013/965140 |
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| author | Kengo Sato Rena Watanabe Fumiko Itoh Masayoshi Shichiri Takuya Watanabe |
| author_facet | Kengo Sato Rena Watanabe Fumiko Itoh Masayoshi Shichiri Takuya Watanabe |
| author_sort | Kengo Sato |
| collection | DOAJ |
| description | Human salusin-α and salusin-β are related peptides produced from prosalusin. Bolus injection of salusin-β into rats induces more profound hypotension and bradycardia than salusin-α. Central administration of salusin-β increases blood pressure via release of norepinephrine and arginine-vasopressin. Circulating levels of salusin-α and salusin-β are lower in patients with essential hypertension. Salusin-β exerts more potent mitogenic effects on human vascular smooth muscle cells (VSMCs) and fibroblasts than salusin-α. Salusin-β accelerates inflammatory responses in human endothelial cells and monocyte-endothelial adhesion. Human macrophage foam cell formation is stimulated by salusin-β but suppressed by salusin-α. Chronic salusin-β infusion into apolipoprotein E-deficient mice enhances atherosclerotic lesions; salusin-α infusion reduces lesions. Salusin-β is expressed in proliferative neointimal lesions of porcine coronary arteries after stenting. Salusin-α and salusin-β immunoreactivity have been detected in human coronary atherosclerotic plaques, with dominance of salusin-β in macrophage foam cells, VSMCs, and fibroblasts. Circulating salusin-β levels increase and salusin-α levels decrease in patients with coronary artery disease. These findings suggest that salusin-β and salusin-α may contribute to proatherogenesis and antiatherogenesis, respectively. Increased salusin-β and/or decreased salusin-α levels in circulating blood and vascular tissue are closely linked with atherosclerosis. Salusin-α and salusin-β could be candidate biomarkers and therapeutic targets for atherosclerotic cardiovascular diseases. |
| format | Article |
| id | doaj-art-100eaf6cee024f16a2ed60b46c5505c8 |
| institution | OA Journals |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-100eaf6cee024f16a2ed60b46c5505c82025-08-20T02:02:32ZengWileyInternational Journal of Hypertension2090-03842090-03922013-01-01201310.1155/2013/965140965140Salusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular DiseasesKengo Sato0Rena Watanabe1Fumiko Itoh2Masayoshi Shichiri3Takuya Watanabe4Laboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanDepartment of Endocrinology, Diabetes and Metabolism, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-Ku, Sagamihara, Kanagawa 252-0374, JapanLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, JapanHuman salusin-α and salusin-β are related peptides produced from prosalusin. Bolus injection of salusin-β into rats induces more profound hypotension and bradycardia than salusin-α. Central administration of salusin-β increases blood pressure via release of norepinephrine and arginine-vasopressin. Circulating levels of salusin-α and salusin-β are lower in patients with essential hypertension. Salusin-β exerts more potent mitogenic effects on human vascular smooth muscle cells (VSMCs) and fibroblasts than salusin-α. Salusin-β accelerates inflammatory responses in human endothelial cells and monocyte-endothelial adhesion. Human macrophage foam cell formation is stimulated by salusin-β but suppressed by salusin-α. Chronic salusin-β infusion into apolipoprotein E-deficient mice enhances atherosclerotic lesions; salusin-α infusion reduces lesions. Salusin-β is expressed in proliferative neointimal lesions of porcine coronary arteries after stenting. Salusin-α and salusin-β immunoreactivity have been detected in human coronary atherosclerotic plaques, with dominance of salusin-β in macrophage foam cells, VSMCs, and fibroblasts. Circulating salusin-β levels increase and salusin-α levels decrease in patients with coronary artery disease. These findings suggest that salusin-β and salusin-α may contribute to proatherogenesis and antiatherogenesis, respectively. Increased salusin-β and/or decreased salusin-α levels in circulating blood and vascular tissue are closely linked with atherosclerosis. Salusin-α and salusin-β could be candidate biomarkers and therapeutic targets for atherosclerotic cardiovascular diseases.http://dx.doi.org/10.1155/2013/965140 |
| spellingShingle | Kengo Sato Rena Watanabe Fumiko Itoh Masayoshi Shichiri Takuya Watanabe Salusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases International Journal of Hypertension |
| title | Salusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases |
| title_full | Salusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases |
| title_fullStr | Salusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases |
| title_full_unstemmed | Salusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases |
| title_short | Salusins: Potential Use as a Biomarker for Atherosclerotic Cardiovascular Diseases |
| title_sort | salusins potential use as a biomarker for atherosclerotic cardiovascular diseases |
| url | http://dx.doi.org/10.1155/2013/965140 |
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