The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort.
<h4>Background</h4>In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal fac...
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2016-01-01
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| author | Esther Roura Noémie Travier Tim Waterboer Silvia de Sanjosé F Xavier Bosch Michael Pawlita Valeria Pala Elisabete Weiderpass Núria Margall Joakim Dillner Inger T Gram Anne Tjønneland Christian Munk Domenico Palli Kay-Tee Khaw Kim Overvad Françoise Clavel-Chapelon Sylvie Mesrine Agnès Fournier Renée T Fortner Jennifer Ose Annika Steffen Antonia Trichopoulou Pagona Lagiou Philippos Orfanos Giovanna Masala Rosario Tumino Carlotta Sacerdote Silvia Polidoro Amalia Mattiello Eiliv Lund Petra H Peeters H B as Bueno-de-Mesquita J Ramón Quirós María-José Sánchez Carmen Navarro Aurelio Barricarte Nerea Larrañaga Johanna Ekström David Lindquist Annika Idahl Ruth C Travis Melissa A Merritt Marc J Gunter Sabina Rinaldi Massimo Tommasino Silvia Franceschi Elio Riboli Xavier Castellsagué |
| author_facet | Esther Roura Noémie Travier Tim Waterboer Silvia de Sanjosé F Xavier Bosch Michael Pawlita Valeria Pala Elisabete Weiderpass Núria Margall Joakim Dillner Inger T Gram Anne Tjønneland Christian Munk Domenico Palli Kay-Tee Khaw Kim Overvad Françoise Clavel-Chapelon Sylvie Mesrine Agnès Fournier Renée T Fortner Jennifer Ose Annika Steffen Antonia Trichopoulou Pagona Lagiou Philippos Orfanos Giovanna Masala Rosario Tumino Carlotta Sacerdote Silvia Polidoro Amalia Mattiello Eiliv Lund Petra H Peeters H B as Bueno-de-Mesquita J Ramón Quirós María-José Sánchez Carmen Navarro Aurelio Barricarte Nerea Larrañaga Johanna Ekström David Lindquist Annika Idahl Ruth C Travis Melissa A Merritt Marc J Gunter Sabina Rinaldi Massimo Tommasino Silvia Franceschi Elio Riboli Xavier Castellsagué |
| author_sort | Esther Roura |
| collection | DOAJ |
| description | <h4>Background</h4>In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC).<h4>Methods and findings</h4>We followed a cohort of 308,036 women recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. At enrollment, participants completed a questionnaire and provided serum. After a 9-year median follow-up, 261 ICC and 804 CIN3/CIS cases were reported. In a nested case-control study, the sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11,16,18,31,33,35,45,52,58, and antibodies against Chlamydia trachomatis and Human herpesvirus 2. Multivariate analyses were performed to estimate hazard ratios (HR), odds ratios (OR) and corresponding 95% confidence intervals (CI). The cohort analysis showed that number of full-term pregnancies was positively associated with CIN3/CIS risk (p-trend = 0.03). Duration of oral contraceptives use was associated with a significantly increased risk of both CIN3/CIS and ICC (HR = 1.6 and HR = 1.8 respectively for ≥ 15 years versus never use). Ever use of menopausal hormone therapy was associated with a reduced risk of ICC (HR = 0.5, 95%CI: 0.4-0.8). A non-significant reduced risk of ICC with ever use of intrauterine devices (IUD) was found in the nested case-control analysis (OR = 0.6). Analyses restricted to all cases and HPV seropositive controls yielded similar results, revealing a significant inverse association with IUD for combined CIN3/CIS and ICC (OR = 0.7).<h4>Conclusions</h4>Even though HPV is the necessary cause of CC, our results suggest that several hormonal factors are risk factors for cervical carcinogenesis. Adherence to current cervical cancer screening guidelines should minimize the increased risk of CC associated with these hormonal risk factors. |
| format | Article |
| id | doaj-art-10061e76bbed42be9cfcaf1fd60f8c2b |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-10061e76bbed42be9cfcaf1fd60f8c2b2025-08-20T03:10:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01111e014702910.1371/journal.pone.0147029The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort.Esther RouraNoémie TravierTim WaterboerSilvia de SanjoséF Xavier BoschMichael PawlitaValeria PalaElisabete WeiderpassNúria MargallJoakim DillnerInger T GramAnne TjønnelandChristian MunkDomenico PalliKay-Tee KhawKim OvervadFrançoise Clavel-ChapelonSylvie MesrineAgnès FournierRenée T FortnerJennifer OseAnnika SteffenAntonia TrichopoulouPagona LagiouPhilippos OrfanosGiovanna MasalaRosario TuminoCarlotta SacerdoteSilvia PolidoroAmalia MattielloEiliv LundPetra H PeetersH B as Bueno-de-MesquitaJ Ramón QuirósMaría-José SánchezCarmen NavarroAurelio BarricarteNerea LarrañagaJohanna EkströmDavid LindquistAnnika IdahlRuth C TravisMelissa A MerrittMarc J GunterSabina RinaldiMassimo TommasinoSilvia FranceschiElio RiboliXavier Castellsagué<h4>Background</h4>In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC).<h4>Methods and findings</h4>We followed a cohort of 308,036 women recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study. At enrollment, participants completed a questionnaire and provided serum. After a 9-year median follow-up, 261 ICC and 804 CIN3/CIS cases were reported. In a nested case-control study, the sera from 609 cases and 1,218 matched controls were tested for L1 antibodies against HPV types 11,16,18,31,33,35,45,52,58, and antibodies against Chlamydia trachomatis and Human herpesvirus 2. Multivariate analyses were performed to estimate hazard ratios (HR), odds ratios (OR) and corresponding 95% confidence intervals (CI). The cohort analysis showed that number of full-term pregnancies was positively associated with CIN3/CIS risk (p-trend = 0.03). Duration of oral contraceptives use was associated with a significantly increased risk of both CIN3/CIS and ICC (HR = 1.6 and HR = 1.8 respectively for ≥ 15 years versus never use). Ever use of menopausal hormone therapy was associated with a reduced risk of ICC (HR = 0.5, 95%CI: 0.4-0.8). A non-significant reduced risk of ICC with ever use of intrauterine devices (IUD) was found in the nested case-control analysis (OR = 0.6). Analyses restricted to all cases and HPV seropositive controls yielded similar results, revealing a significant inverse association with IUD for combined CIN3/CIS and ICC (OR = 0.7).<h4>Conclusions</h4>Even though HPV is the necessary cause of CC, our results suggest that several hormonal factors are risk factors for cervical carcinogenesis. Adherence to current cervical cancer screening guidelines should minimize the increased risk of CC associated with these hormonal risk factors.https://doi.org/10.1371/journal.pone.0147029 |
| spellingShingle | Esther Roura Noémie Travier Tim Waterboer Silvia de Sanjosé F Xavier Bosch Michael Pawlita Valeria Pala Elisabete Weiderpass Núria Margall Joakim Dillner Inger T Gram Anne Tjønneland Christian Munk Domenico Palli Kay-Tee Khaw Kim Overvad Françoise Clavel-Chapelon Sylvie Mesrine Agnès Fournier Renée T Fortner Jennifer Ose Annika Steffen Antonia Trichopoulou Pagona Lagiou Philippos Orfanos Giovanna Masala Rosario Tumino Carlotta Sacerdote Silvia Polidoro Amalia Mattiello Eiliv Lund Petra H Peeters H B as Bueno-de-Mesquita J Ramón Quirós María-José Sánchez Carmen Navarro Aurelio Barricarte Nerea Larrañaga Johanna Ekström David Lindquist Annika Idahl Ruth C Travis Melissa A Merritt Marc J Gunter Sabina Rinaldi Massimo Tommasino Silvia Franceschi Elio Riboli Xavier Castellsagué The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. PLoS ONE |
| title | The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. |
| title_full | The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. |
| title_fullStr | The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. |
| title_full_unstemmed | The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. |
| title_short | The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. |
| title_sort | influence of hormonal factors on the risk of developing cervical cancer and pre cancer results from the epic cohort |
| url | https://doi.org/10.1371/journal.pone.0147029 |
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