Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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American Chemical Society
2025-08-01
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| Series: | ACS Omega |
| Online Access: | https://doi.org/10.1021/acsomega.5c06242 |
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| author | Kulpornsorn Isswanich Pattara Poungcho Koonchira Buaban Hathaichanok Chuntakaruk Kamonpan Sanachai Chaisak Chansriniyom Thanyada Rungrotmongkol Wanchai De-Eknamkul Supakarn Chamni |
| author_facet | Kulpornsorn Isswanich Pattara Poungcho Koonchira Buaban Hathaichanok Chuntakaruk Kamonpan Sanachai Chaisak Chansriniyom Thanyada Rungrotmongkol Wanchai De-Eknamkul Supakarn Chamni |
| author_sort | Kulpornsorn Isswanich |
| collection | DOAJ |
| format | Article |
| id | doaj-art-10058c879a3446bf988ee86754b7a7ad |
| institution | Kabale University |
| issn | 2470-1343 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | American Chemical Society |
| record_format | Article |
| series | ACS Omega |
| spelling | doaj-art-10058c879a3446bf988ee86754b7a7ad2025-08-26T08:11:16ZengAmerican Chemical SocietyACS Omega2470-13432025-08-011033382113822810.1021/acsomega.5c06242Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico StudiesKulpornsorn Isswanich0Pattara Poungcho1Koonchira Buaban2Hathaichanok Chuntakaruk3Kamonpan Sanachai4Chaisak Chansriniyom5Thanyada Rungrotmongkol6Wanchai De-Eknamkul7Supakarn Chamni8Pharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandPharmaceutical Sciences and Technology Program, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Structural and Computational Biology, Faculty of Science, Chulalongkorn University, Bangkok, ThailandDepartment of Biochemistry, Faculty of Science, Khon Kaen University, Khon Kaen, ThailandDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandCenter of Excellence in Structural and Computational Biology, Faculty of Science, Chulalongkorn University, Bangkok, ThailandDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, ThailandDepartment of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailandhttps://doi.org/10.1021/acsomega.5c06242 |
| spellingShingle | Kulpornsorn Isswanich Pattara Poungcho Koonchira Buaban Hathaichanok Chuntakaruk Kamonpan Sanachai Chaisak Chansriniyom Thanyada Rungrotmongkol Wanchai De-Eknamkul Supakarn Chamni Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies ACS Omega |
| title | Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies |
| title_full | Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies |
| title_fullStr | Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies |
| title_full_unstemmed | Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies |
| title_short | Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies |
| title_sort | natural product inspired bis trifluoromethyl phenyl hydroxycinnamate derivatives as promising nonsteroidal inhibitors of human steroid 5α reductase type 1 synthesis in vitro and in silico studies |
| url | https://doi.org/10.1021/acsomega.5c06242 |
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