Dietary and lifestyle interventions in ADPKD – a review of current literature
Background and aim. Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary nephropathy. The only approved therapeutic option is tolvaptan, which has limited availability. Disease-modifying interventions are a topic of strong interest, and with growing understanding of me...
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Nicolaus Copernicus University in Toruń
2025-07-01
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| Series: | Quality in Sport |
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| Online Access: | https://apcz.umk.pl/QS/article/view/61451 |
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| author | Martyna Skweres Szymon Pucyło |
| author_facet | Martyna Skweres Szymon Pucyło |
| author_sort | Martyna Skweres |
| collection | DOAJ |
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Background and aim. Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary nephropathy. The only approved therapeutic option is tolvaptan, which has limited availability. Disease-modifying interventions are a topic of strong interest, and with growing understanding of metabolic pathways that are disrupted in ADPKD, new therapeutic possibilities are being explored. This review discusses the promising role of dietary and lifestyle interventions in management of ADPKD.
Materials and methods. The paper analyzes studies in databases such as PubMed, Google Scholar, ResearchGate, and other scientific databases. Clinical trials, double-blind randomized controlled trials, meta-analyses, systematic reviews, and other review articles were included in the study.
Conclusions. Among interventions that have established disease-modifying potential in pre-clinical studies are dietary interventions leading to induction of ketosis, which has been shown to slow cyst growth in pre-clinical studies. However, little is known about long term benefits and safety of such interventions. Increased water intake and low salt consumption also have the potential to slow cystogenesis, but current research remains inconclusive regarding their efficacy. Lifestyle interventions such as physical activity and cessation of smoking play an important role in management of common comorbidities and help improve quality of life. Further research is necessary in order to establish optimal dietary treatment that corresponds to ADPKD patients’ specific metabolic needs.
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| format | Article |
| id | doaj-art-10025a2a5c944bb0aba7c078d1b09396 |
| institution | OA Journals |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-10025a2a5c944bb0aba7c078d1b093962025-08-20T02:35:57ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-07-014310.12775/QS.2025.43.61451Dietary and lifestyle interventions in ADPKD – a review of current literatureMartyna Skweres0https://orcid.org/0009-0003-1228-7918Szymon Pucyło1https://orcid.org/0009-0007-0143-7115National Medical Institute of the Ministry of the Interior and Administration, Wołoska 137, 02-507 Warsaw, PolandMiedzylesie Specialist Hospital in Warsaw, Bursztynowa 2, 04-749 Warsaw, Poland Background and aim. Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary nephropathy. The only approved therapeutic option is tolvaptan, which has limited availability. Disease-modifying interventions are a topic of strong interest, and with growing understanding of metabolic pathways that are disrupted in ADPKD, new therapeutic possibilities are being explored. This review discusses the promising role of dietary and lifestyle interventions in management of ADPKD. Materials and methods. The paper analyzes studies in databases such as PubMed, Google Scholar, ResearchGate, and other scientific databases. Clinical trials, double-blind randomized controlled trials, meta-analyses, systematic reviews, and other review articles were included in the study. Conclusions. Among interventions that have established disease-modifying potential in pre-clinical studies are dietary interventions leading to induction of ketosis, which has been shown to slow cyst growth in pre-clinical studies. However, little is known about long term benefits and safety of such interventions. Increased water intake and low salt consumption also have the potential to slow cystogenesis, but current research remains inconclusive regarding their efficacy. Lifestyle interventions such as physical activity and cessation of smoking play an important role in management of common comorbidities and help improve quality of life. Further research is necessary in order to establish optimal dietary treatment that corresponds to ADPKD patients’ specific metabolic needs. https://apcz.umk.pl/QS/article/view/61451autosomal dominant kidney diseasechronic kidney diseaseketogenic dietphysical activitydietary intervention |
| spellingShingle | Martyna Skweres Szymon Pucyło Dietary and lifestyle interventions in ADPKD – a review of current literature Quality in Sport autosomal dominant kidney disease chronic kidney disease ketogenic diet physical activity dietary intervention |
| title | Dietary and lifestyle interventions in ADPKD – a review of current literature |
| title_full | Dietary and lifestyle interventions in ADPKD – a review of current literature |
| title_fullStr | Dietary and lifestyle interventions in ADPKD – a review of current literature |
| title_full_unstemmed | Dietary and lifestyle interventions in ADPKD – a review of current literature |
| title_short | Dietary and lifestyle interventions in ADPKD – a review of current literature |
| title_sort | dietary and lifestyle interventions in adpkd a review of current literature |
| topic | autosomal dominant kidney disease chronic kidney disease ketogenic diet physical activity dietary intervention |
| url | https://apcz.umk.pl/QS/article/view/61451 |
| work_keys_str_mv | AT martynaskweres dietaryandlifestyleinterventionsinadpkdareviewofcurrentliterature AT szymonpucyło dietaryandlifestyleinterventionsinadpkdareviewofcurrentliterature |