Mechanisms of vascular aging
Vascular aging plays a key role in morbidity and mortality in the elderly. With age, the vasculature undergoes changes characterized by endothelial dysfunction, wall thickening, decreased elongation, and arterial stiffness. The review focuses on the main cellular and molecular mechanisms of aging, i...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2022-07-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/4829 |
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| author | E. M. Stakhneva E. V. Kashtanova Ya. V. Polonskaya V. S. Shramko Yu. I. Ragino |
| author_facet | E. M. Stakhneva E. V. Kashtanova Ya. V. Polonskaya V. S. Shramko Yu. I. Ragino |
| author_sort | E. M. Stakhneva |
| collection | DOAJ |
| description | Vascular aging plays a key role in morbidity and mortality in the elderly. With age, the vasculature undergoes changes characterized by endothelial dysfunction, wall thickening, decreased elongation, and arterial stiffness. The review focuses on the main cellular and molecular mechanisms of aging, including oxidative stress, endothelial dysfunction, inflammation, increased arterial stiffness, and molecular genetic aspects. Their role in the pathogenesis of diseases associated with aging is considered. Some of the molecular mechanisms underlying these processes include increased expression and activation of matrix metalloproteinases, activation of transforming growth factor β1 signaling, increased levels of C-reactive protein, interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)α, and N-terminal pro B-type natriuretic peptide (NT-pro-BNP), and activation of proinflammatory signaling pathways. These events can be caused by vasoactive agents, such as angiotensin II and endothelin-1, the levels of which increase with aging. For prevention of cardiovascular diseases, it is important to understand the mechanisms underlying age-related pathophysiological changes in the blood vessels. |
| format | Article |
| id | doaj-art-10013d6f9481498faef459a05e25a5a4 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-10013d6f9481498faef459a05e25a5a42025-08-20T03:37:46ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842022-07-0121218619410.20538/1682-0363-2022-2-186-1942905Mechanisms of vascular agingE. M. Stakhneva0E. V. Kashtanova1Ya. V. Polonskaya2V. S. Shramko3Yu. I. Ragino4Research Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesResearch Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesResearch Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesResearch Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesResearch Institute of Internal and Preventive Medicine – Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of SciencesVascular aging plays a key role in morbidity and mortality in the elderly. With age, the vasculature undergoes changes characterized by endothelial dysfunction, wall thickening, decreased elongation, and arterial stiffness. The review focuses on the main cellular and molecular mechanisms of aging, including oxidative stress, endothelial dysfunction, inflammation, increased arterial stiffness, and molecular genetic aspects. Their role in the pathogenesis of diseases associated with aging is considered. Some of the molecular mechanisms underlying these processes include increased expression and activation of matrix metalloproteinases, activation of transforming growth factor β1 signaling, increased levels of C-reactive protein, interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)α, and N-terminal pro B-type natriuretic peptide (NT-pro-BNP), and activation of proinflammatory signaling pathways. These events can be caused by vasoactive agents, such as angiotensin II and endothelin-1, the levels of which increase with aging. For prevention of cardiovascular diseases, it is important to understand the mechanisms underlying age-related pathophysiological changes in the blood vessels.https://bulletin.ssmu.ru/jour/article/view/4829vascular agingcardiovascular diseaseoxidative stressendothelial dysfunction |
| spellingShingle | E. M. Stakhneva E. V. Kashtanova Ya. V. Polonskaya V. S. Shramko Yu. I. Ragino Mechanisms of vascular aging Бюллетень сибирской медицины vascular aging cardiovascular disease oxidative stress endothelial dysfunction |
| title | Mechanisms of vascular aging |
| title_full | Mechanisms of vascular aging |
| title_fullStr | Mechanisms of vascular aging |
| title_full_unstemmed | Mechanisms of vascular aging |
| title_short | Mechanisms of vascular aging |
| title_sort | mechanisms of vascular aging |
| topic | vascular aging cardiovascular disease oxidative stress endothelial dysfunction |
| url | https://bulletin.ssmu.ru/jour/article/view/4829 |
| work_keys_str_mv | AT emstakhneva mechanismsofvascularaging AT evkashtanova mechanismsofvascularaging AT yavpolonskaya mechanismsofvascularaging AT vsshramko mechanismsofvascularaging AT yuiragino mechanismsofvascularaging |