Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysis
Abstract Follicular dendritic cell sarcoma (FDCS), an infrequent malignancy, poses diagnostic challenges due to its nonspecific clinical presentations and propensity for recurrence and metastasis, particularly when assessed through imaging modalities. Accurate diagnosis relies heavily on pathologica...
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| Format: | Article |
| Language: | English |
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BMC
2025-02-01
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| Series: | Diagnostic Pathology |
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| Online Access: | https://doi.org/10.1186/s13000-025-01614-5 |
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| _version_ | 1850198122503864320 |
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| author | Yuchen Jing Hua Ye Shuai Luo Jinjing Wang |
| author_facet | Yuchen Jing Hua Ye Shuai Luo Jinjing Wang |
| author_sort | Yuchen Jing |
| collection | DOAJ |
| description | Abstract Follicular dendritic cell sarcoma (FDCS), an infrequent malignancy, poses diagnostic challenges due to its nonspecific clinical presentations and propensity for recurrence and metastasis, particularly when assessed through imaging modalities. Accurate diagnosis relies heavily on pathological morphology and immunohistochemical analysis. This study examines two FDCS cases from the Affiliated Hospital of Zunyi Medical University. Next-generation sequencing (NGS) identified three gene rearrangements—HFM1::BIRC3, ELF4::AIFM1, and DIP2B::WIF1 —in one case, while no genetic alterations were detected in the other. The report explores clinicopathological characteristics, molecular genetics, differential diagnosis, therapeutic approaches, and prognosis to enhance diagnostic and pathological understanding of FDCS in medical practice. |
| format | Article |
| id | doaj-art-0ffb37cce879497c8ed587dafea546fd |
| institution | OA Journals |
| issn | 1746-1596 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj-art-0ffb37cce879497c8ed587dafea546fd2025-08-20T02:12:57ZengBMCDiagnostic Pathology1746-15962025-02-0120111110.1186/s13000-025-01614-5Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysisYuchen Jing0Hua Ye1Shuai Luo2Jinjing Wang3Department of Pathology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Pathology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Pathology, Affiliated Hospital of Zunyi Medical UniversityDepartment of Pathology, Affiliated Hospital of Zunyi Medical UniversityAbstract Follicular dendritic cell sarcoma (FDCS), an infrequent malignancy, poses diagnostic challenges due to its nonspecific clinical presentations and propensity for recurrence and metastasis, particularly when assessed through imaging modalities. Accurate diagnosis relies heavily on pathological morphology and immunohistochemical analysis. This study examines two FDCS cases from the Affiliated Hospital of Zunyi Medical University. Next-generation sequencing (NGS) identified three gene rearrangements—HFM1::BIRC3, ELF4::AIFM1, and DIP2B::WIF1 —in one case, while no genetic alterations were detected in the other. The report explores clinicopathological characteristics, molecular genetics, differential diagnosis, therapeutic approaches, and prognosis to enhance diagnostic and pathological understanding of FDCS in medical practice.https://doi.org/10.1186/s13000-025-01614-5Follicular dendritic cell sarcomaPathologyNext-generation sequencingDifferential diagnosisTreatment |
| spellingShingle | Yuchen Jing Hua Ye Shuai Luo Jinjing Wang Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysis Diagnostic Pathology Follicular dendritic cell sarcoma Pathology Next-generation sequencing Differential diagnosis Treatment |
| title | Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysis |
| title_full | Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysis |
| title_fullStr | Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysis |
| title_full_unstemmed | Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysis |
| title_short | Description of two cases of follicular dendritic cell sarcoma, including next-generation sequencing analysis |
| title_sort | description of two cases of follicular dendritic cell sarcoma including next generation sequencing analysis |
| topic | Follicular dendritic cell sarcoma Pathology Next-generation sequencing Differential diagnosis Treatment |
| url | https://doi.org/10.1186/s13000-025-01614-5 |
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