Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage
Introduction Estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR) are insensitive biomarkers for early detection of hypertension-mediated organ damage (HMOD). In this nationwide cross-sectional study, we assessed potential biomarkers for early HMOD in healthy persons...
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Taylor & Francis Group
2024-12-01
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| Series: | Blood Pressure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/08037051.2024.2323980 |
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| author | Karl Marius Brobak Lene V. Halvorsen Hans Christian D. Aass Camilla L. Søraas Arleen Aune Eirik Olsen Ola Undrum Bergland Stine Rognstad Kjersti B. Blom Jon Arne K. Birkeland Aud Høieggen Anne Cecilie K. Larstorp Marit D. Solbu |
| author_facet | Karl Marius Brobak Lene V. Halvorsen Hans Christian D. Aass Camilla L. Søraas Arleen Aune Eirik Olsen Ola Undrum Bergland Stine Rognstad Kjersti B. Blom Jon Arne K. Birkeland Aud Høieggen Anne Cecilie K. Larstorp Marit D. Solbu |
| author_sort | Karl Marius Brobak |
| collection | DOAJ |
| description | Introduction Estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR) are insensitive biomarkers for early detection of hypertension-mediated organ damage (HMOD). In this nationwide cross-sectional study, we assessed potential biomarkers for early HMOD in healthy persons and patients with hypertension. We hypothesised that plasma levels of biomarkers: (1) are different between healthy controls and patients with hypertension, (2): can classify patients with hypertension according to the degree of hypertension severity.Design and methods Patients with hypertension prescribed ≥2 antihypertensive agents were selected from a multicentre study. Healthy controls were selected from an ongoing study of living kidney donor candidates. Uncontrolled hypertension was defined as systolic daytime ambulatory blood pressure ≥135 mmHg. Kidney HMOD was defined by ACR > 3.0 mg/mmol or eGFR < 60 mL/min/1.73 m2. Patients with hypertension were categorised into three groups: (1) controlled hypertension; (2) uncontrolled hypertension without kidney HMOD; (3) uncontrolled hypertension with kidney HMOD. Fifteen biomarkers were analysed using a Luminex bead-based immunoassay, and nine fell within the specified analytical range.Results Plasma levels of Interleukin 1 receptor antagonist (IL-1RA), neutrophil gelatinase-associated lipocalin (NGAL) and uromodulin were significantly different between healthy controls (n = 39) and patients with hypertension (n = 176). In regression models, with controlled hypertension (n = 55) as the reference category, none of the biomarkers were associated with uncontrolled hypertension without (n = 59) and with (n = 62) kidney HMOD. In models adjusted for cardiovascular risk factors and eGFR, osteopontin (OPN) was associated with uncontrolled hypertension without kidney HMOD (odds ratio (OR) 1.77 (1.05–2.98), p = 0.03), and regulated upon activation normal T-cell expressed and secreted (RANTES) with uncontrolled hypertension with kidney HMOD (OR 0.57 (0.34–0.95), p = 0.03).Conclusions None of the biomarkers could differentiate our hypertension groups when established risk factors were considered. Plasma OPN may identify patients with uncontrolled hypertension at risk for kidney HMOD. |
| format | Article |
| id | doaj-art-0ffb2fdb14a74c66a8326310940cb73c |
| institution | OA Journals |
| issn | 0803-7051 1651-1999 |
| language | English |
| publishDate | 2024-12-01 |
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| series | Blood Pressure |
| spelling | doaj-art-0ffb2fdb14a74c66a8326310940cb73c2025-08-20T02:08:38ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992024-12-0133110.1080/08037051.2024.2323980Novel biomarkers in patients with uncontrolled hypertension with and without kidney damageKarl Marius Brobak0Lene V. Halvorsen1Hans Christian D. Aass2Camilla L. Søraas3Arleen Aune4Eirik Olsen5Ola Undrum Bergland6Stine Rognstad7Kjersti B. Blom8Jon Arne K. Birkeland9Aud Høieggen10Anne Cecilie K. Larstorp11Marit D. Solbu12Section of Nephrology, University Hospital of North Norway, Tromsø, NorwayDepartment of Nephrology, Oslo University Hospital Ullevål, Oslo, NorwayDepartment of Medical Biochemistry, Oslo University Hospital Ullevål, Oslo, NorwaySection for Cardiovascular and Renal Research, Oslo University Hospital Ullevål, Oslo, NorwayDepartment of Heart Disease, Haukeland University Hospital, Bergen, NorwayClinic of Emergency Medicine and Prehospital Care, Trondheim University Hospital, Trondheim, NorwaySection for Cardiovascular and Renal Research, Oslo University Hospital Ullevål, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwayDepartment of Nephrology, Oslo University Hospital Ullevål, Oslo, NorwayDepartment of Nephrology, Oslo University Hospital Ullevål, Oslo, NorwayDepartment of Nephrology, Oslo University Hospital Ullevål, Oslo, NorwayInstitute of Clinical Medicine, University of Oslo, Oslo, NorwaySection of Nephrology, University Hospital of North Norway, Tromsø, NorwayIntroduction Estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR) are insensitive biomarkers for early detection of hypertension-mediated organ damage (HMOD). In this nationwide cross-sectional study, we assessed potential biomarkers for early HMOD in healthy persons and patients with hypertension. We hypothesised that plasma levels of biomarkers: (1) are different between healthy controls and patients with hypertension, (2): can classify patients with hypertension according to the degree of hypertension severity.Design and methods Patients with hypertension prescribed ≥2 antihypertensive agents were selected from a multicentre study. Healthy controls were selected from an ongoing study of living kidney donor candidates. Uncontrolled hypertension was defined as systolic daytime ambulatory blood pressure ≥135 mmHg. Kidney HMOD was defined by ACR > 3.0 mg/mmol or eGFR < 60 mL/min/1.73 m2. Patients with hypertension were categorised into three groups: (1) controlled hypertension; (2) uncontrolled hypertension without kidney HMOD; (3) uncontrolled hypertension with kidney HMOD. Fifteen biomarkers were analysed using a Luminex bead-based immunoassay, and nine fell within the specified analytical range.Results Plasma levels of Interleukin 1 receptor antagonist (IL-1RA), neutrophil gelatinase-associated lipocalin (NGAL) and uromodulin were significantly different between healthy controls (n = 39) and patients with hypertension (n = 176). In regression models, with controlled hypertension (n = 55) as the reference category, none of the biomarkers were associated with uncontrolled hypertension without (n = 59) and with (n = 62) kidney HMOD. In models adjusted for cardiovascular risk factors and eGFR, osteopontin (OPN) was associated with uncontrolled hypertension without kidney HMOD (odds ratio (OR) 1.77 (1.05–2.98), p = 0.03), and regulated upon activation normal T-cell expressed and secreted (RANTES) with uncontrolled hypertension with kidney HMOD (OR 0.57 (0.34–0.95), p = 0.03).Conclusions None of the biomarkers could differentiate our hypertension groups when established risk factors were considered. Plasma OPN may identify patients with uncontrolled hypertension at risk for kidney HMOD.https://www.tandfonline.com/doi/10.1080/08037051.2024.2323980Hypertensionhypertension-mediated organ damage (HMOD)kidney damageinflammationfibrosis |
| spellingShingle | Karl Marius Brobak Lene V. Halvorsen Hans Christian D. Aass Camilla L. Søraas Arleen Aune Eirik Olsen Ola Undrum Bergland Stine Rognstad Kjersti B. Blom Jon Arne K. Birkeland Aud Høieggen Anne Cecilie K. Larstorp Marit D. Solbu Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage Blood Pressure Hypertension hypertension-mediated organ damage (HMOD) kidney damage inflammation fibrosis |
| title | Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage |
| title_full | Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage |
| title_fullStr | Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage |
| title_full_unstemmed | Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage |
| title_short | Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage |
| title_sort | novel biomarkers in patients with uncontrolled hypertension with and without kidney damage |
| topic | Hypertension hypertension-mediated organ damage (HMOD) kidney damage inflammation fibrosis |
| url | https://www.tandfonline.com/doi/10.1080/08037051.2024.2323980 |
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