Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis
Abstract Objective To assess the lactate/albumin ratio (L/A) as a prognostic biomarker for differentiating in-hospital mortality risk in pediatric patients with necrotizing enterocolitis (NEC). Methods We performed a retrospective study utilizing the Pediatric Intensive Care (PIC) database. Patients...
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BMC
2025-02-01
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| Online Access: | https://doi.org/10.1186/s12887-025-05439-5 |
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| author | Ban Li Yuanzhi Chen Zhen Yang Xianglun Sun Cheng Tian Jingsi Liu Lihua Yuan Kanglin Dai |
| author_facet | Ban Li Yuanzhi Chen Zhen Yang Xianglun Sun Cheng Tian Jingsi Liu Lihua Yuan Kanglin Dai |
| author_sort | Ban Li |
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| description | Abstract Objective To assess the lactate/albumin ratio (L/A) as a prognostic biomarker for differentiating in-hospital mortality risk in pediatric patients with necrotizing enterocolitis (NEC). Methods We performed a retrospective study utilizing the Pediatric Intensive Care (PIC) database. Patients diagnosed with NEC were categorized into a discharge group and a death group based on in-hospital outcomes. The association between L/A and in-hospital mortality was assessed using logistic regression models. Results After inclusion and exclusion criteria, 100 NEC patients were included in the study, with 87 survivors and 13 deaths. The mean age at admission was 21.6 ± 2.4 days, and the mean weight was 2.1 ± 0.1 kg. Significant differences in creatinine, international normalized ratio (INR) and L/A were observed between the groups (p < 0.05). The L/A ratio was a substantial predictor of in-hospital mortality, with an odds ratio (OR) of 5.24 (95% CI: 1.51–18.20, p = 0.01). An L/A cutoff value of 0.56 demonstrated a sensitivity of 0.923 and specificity of 0.486, with an AUC of 0.725 from the ROC curve analysis. Patients with an L/A ratio of ≥ 0.56 had a higher risk of in-hospital mortality (OR = 11.35, 95% CI: 1.40-91.93, p = 0.02). Conclusion Our study suggested that the L/A ratio may serve as a reliable prognostic indicator for in-hospital mortality in NEC. However, given the limitations of our research, more prospective studies are still needed in the future to test the predictive value of L/A ratio for the prognosis of NEC disease. Clinical trial number Not applicable. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Pediatrics |
| spelling | doaj-art-0ff3f27a771f4beebf2fadf1d23954c02025-02-09T12:54:37ZengBMCBMC Pediatrics1471-24312025-02-012511610.1186/s12887-025-05439-5Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitisBan Li0Yuanzhi Chen1Zhen Yang2Xianglun Sun3Cheng Tian4Jingsi Liu5Lihua Yuan6Kanglin Dai7Division of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen HospitalThe Third Affiliated Hospital of Guangzhou Medical UniversityDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen HospitalDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen HospitalDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen HospitalDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen HospitalDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen HospitalDivision of Pediatric Surgery, Department of Surgery, The University of Hong Kong-Shenzhen HospitalAbstract Objective To assess the lactate/albumin ratio (L/A) as a prognostic biomarker for differentiating in-hospital mortality risk in pediatric patients with necrotizing enterocolitis (NEC). Methods We performed a retrospective study utilizing the Pediatric Intensive Care (PIC) database. Patients diagnosed with NEC were categorized into a discharge group and a death group based on in-hospital outcomes. The association between L/A and in-hospital mortality was assessed using logistic regression models. Results After inclusion and exclusion criteria, 100 NEC patients were included in the study, with 87 survivors and 13 deaths. The mean age at admission was 21.6 ± 2.4 days, and the mean weight was 2.1 ± 0.1 kg. Significant differences in creatinine, international normalized ratio (INR) and L/A were observed between the groups (p < 0.05). The L/A ratio was a substantial predictor of in-hospital mortality, with an odds ratio (OR) of 5.24 (95% CI: 1.51–18.20, p = 0.01). An L/A cutoff value of 0.56 demonstrated a sensitivity of 0.923 and specificity of 0.486, with an AUC of 0.725 from the ROC curve analysis. Patients with an L/A ratio of ≥ 0.56 had a higher risk of in-hospital mortality (OR = 11.35, 95% CI: 1.40-91.93, p = 0.02). Conclusion Our study suggested that the L/A ratio may serve as a reliable prognostic indicator for in-hospital mortality in NEC. However, given the limitations of our research, more prospective studies are still needed in the future to test the predictive value of L/A ratio for the prognosis of NEC disease. Clinical trial number Not applicable.https://doi.org/10.1186/s12887-025-05439-5Neonatal necrotizing enterocolitisLactate/albumin ratioPediatric intensive care databaseIn-hospital mortality |
| spellingShingle | Ban Li Yuanzhi Chen Zhen Yang Xianglun Sun Cheng Tian Jingsi Liu Lihua Yuan Kanglin Dai Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis BMC Pediatrics Neonatal necrotizing enterocolitis Lactate/albumin ratio Pediatric intensive care database In-hospital mortality |
| title | Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis |
| title_full | Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis |
| title_fullStr | Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis |
| title_full_unstemmed | Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis |
| title_short | Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis |
| title_sort | lactate albumin ratio as a prognostic biomarker for in hospital mortality in pediatric patients with necrotizing enterocolitis |
| topic | Neonatal necrotizing enterocolitis Lactate/albumin ratio Pediatric intensive care database In-hospital mortality |
| url | https://doi.org/10.1186/s12887-025-05439-5 |
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