The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study
Background The mortality rate of patients with sepsis-associated acute kidney injury (SA-AKI) in the intensive care unit (ICU) is high, and there is a need for early identification of SA-AKI patients with poor prognoses. This study investigated the relationship between the lactate dehydrogenase to s...
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| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2212080 |
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| author | Minghao Liang Xiuhong Ren Di Huang Zhishen Ruan Xianhai Chen Zhanjun Qiu |
| author_facet | Minghao Liang Xiuhong Ren Di Huang Zhishen Ruan Xianhai Chen Zhanjun Qiu |
| author_sort | Minghao Liang |
| collection | DOAJ |
| description | Background The mortality rate of patients with sepsis-associated acute kidney injury (SA-AKI) in the intensive care unit (ICU) is high, and there is a need for early identification of SA-AKI patients with poor prognoses. This study investigated the relationship between the lactate dehydrogenase to serum albumin ratio (LAR) and prognosis in patients with SA-AKI.Methods We performed a retrospective cohort study of patients with SA-AKI who are represented in the Medical Information Mart for Intensive Care IV (MIMIC-IV). We used multivariable Cox regression analysis to determine adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Subgroup analysis, survival curves, and curve fitting were used to evaluate a connection between the LAR and prognosis in patients with SA-AKI.Results There were a total of 6453 participants in this research. The average age of the participants was 63.9 ± 16.1 years, and the average LAR was 11.0 (7.6, 17.7)/IU/g. After controlling for variables, the HRs for 28-day mortality were 1.20 (HR: 1.20, 95% CI: 1.05–1.38, p = 0.008) and 1.61 (HR: 1.61, 95% CI: 1.41–1.84, p < 0.001) for Tertile 2 (T2, 8.59≤ LAR< 14.66) and Tertile 3 (T3, LAR ≥ 14.66), respectively, compared to Tertile 1 (T1, LAR < 8.59). The outcomes for 90-day mortality and in-hospital death rate were comparable. The Kaplan–Meier (KM) analysis revealed that the group with greater LAR had higher 28-day and 90-day death rates.Conclusion Our study shows that LAR is associated with poor prognosis in patients with SA-AKI. Higher LAR is associated with higher 28-day, 90-day, and in-hospital mortality. |
| format | Article |
| id | doaj-art-0ff354063c8e4991bea6ae4c0ff3e974 |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-0ff354063c8e4991bea6ae4c0ff3e9742025-08-20T02:28:45ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492023-12-0145110.1080/0886022X.2023.2212080The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort studyMinghao Liang0Xiuhong Ren1Di Huang2Zhishen Ruan3Xianhai Chen4Zhanjun Qiu5College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaSchool of Nursing, Shandong University of Traditional Chinese Medicine, Jinan, ChinaFirst Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaFirst Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan, ChinaThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaThe Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaBackground The mortality rate of patients with sepsis-associated acute kidney injury (SA-AKI) in the intensive care unit (ICU) is high, and there is a need for early identification of SA-AKI patients with poor prognoses. This study investigated the relationship between the lactate dehydrogenase to serum albumin ratio (LAR) and prognosis in patients with SA-AKI.Methods We performed a retrospective cohort study of patients with SA-AKI who are represented in the Medical Information Mart for Intensive Care IV (MIMIC-IV). We used multivariable Cox regression analysis to determine adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Subgroup analysis, survival curves, and curve fitting were used to evaluate a connection between the LAR and prognosis in patients with SA-AKI.Results There were a total of 6453 participants in this research. The average age of the participants was 63.9 ± 16.1 years, and the average LAR was 11.0 (7.6, 17.7)/IU/g. After controlling for variables, the HRs for 28-day mortality were 1.20 (HR: 1.20, 95% CI: 1.05–1.38, p = 0.008) and 1.61 (HR: 1.61, 95% CI: 1.41–1.84, p < 0.001) for Tertile 2 (T2, 8.59≤ LAR< 14.66) and Tertile 3 (T3, LAR ≥ 14.66), respectively, compared to Tertile 1 (T1, LAR < 8.59). The outcomes for 90-day mortality and in-hospital death rate were comparable. The Kaplan–Meier (KM) analysis revealed that the group with greater LAR had higher 28-day and 90-day death rates.Conclusion Our study shows that LAR is associated with poor prognosis in patients with SA-AKI. Higher LAR is associated with higher 28-day, 90-day, and in-hospital mortality.https://www.tandfonline.com/doi/10.1080/0886022X.2023.2212080Sepsis-associated acute kidney injurylactate dehydrogenase to albumin ratioprognosisMIMIC-IVSA-AKI |
| spellingShingle | Minghao Liang Xiuhong Ren Di Huang Zhishen Ruan Xianhai Chen Zhanjun Qiu The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study Renal Failure Sepsis-associated acute kidney injury lactate dehydrogenase to albumin ratio prognosis MIMIC-IV SA-AKI |
| title | The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study |
| title_full | The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study |
| title_fullStr | The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study |
| title_full_unstemmed | The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study |
| title_short | The association between lactate dehydrogenase to serum albumin ratio and the 28-day mortality in patients with sepsis-associated acute kidney injury in intensive care: a retrospective cohort study |
| title_sort | association between lactate dehydrogenase to serum albumin ratio and the 28 day mortality in patients with sepsis associated acute kidney injury in intensive care a retrospective cohort study |
| topic | Sepsis-associated acute kidney injury lactate dehydrogenase to albumin ratio prognosis MIMIC-IV SA-AKI |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2023.2212080 |
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