Concurrent Thyroid Storm From Postpartum Thyroiditis and Lymphocytic Hypophysitis: A Rare Case
ABSTRACT Postpartum autoimmune thyroiditis (PAT) and lymphocytic hypophysitis (LH) are rare autoimmune conditions occurring during or after pregnancy. We present a case of a 35‐year‐old woman who developed thyroid storm because of PAT followed by LH, resulting in panhypopituitarism. Initial presenta...
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| Language: | English |
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Wiley
2025-05-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.9629 |
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| author | Chalothorn Wannaphut Sakditad Saowapa Vitchapong Prasitsumrit Kamonkiat Wirunsawanya |
| author_facet | Chalothorn Wannaphut Sakditad Saowapa Vitchapong Prasitsumrit Kamonkiat Wirunsawanya |
| author_sort | Chalothorn Wannaphut |
| collection | DOAJ |
| description | ABSTRACT Postpartum autoimmune thyroiditis (PAT) and lymphocytic hypophysitis (LH) are rare autoimmune conditions occurring during or after pregnancy. We present a case of a 35‐year‐old woman who developed thyroid storm because of PAT followed by LH, resulting in panhypopituitarism. Initial presentation included hemodynamic instability, altered consciousness, and hyperthyroid symptoms. She was treated for thyroid storm and subsequently developed hypernatremia, suggestive of diabetes insipidus. MRI revealed features consistent with LH. This case highlights the complex interplay between immune dysregulation and pregnancy‐related hormonal changes, leading to concurrent autoimmune thyroiditis and hypophysitis. Prompt recognition and multidisciplinary management involving endocrinology, obstetrics, and critical care are essential for optimizing outcomes in such cases. Further research is needed to elucidate the underlying mechanisms and refine management strategies for these rare but potentially serious endocrine complications in the postpartum period. |
| format | Article |
| id | doaj-art-0fedb6c850b84e748d5ec804b574e29d |
| institution | OA Journals |
| issn | 2050-0904 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj-art-0fedb6c850b84e748d5ec804b574e29d2025-08-20T01:56:46ZengWileyClinical Case Reports2050-09042025-05-01135n/an/a10.1002/ccr3.9629Concurrent Thyroid Storm From Postpartum Thyroiditis and Lymphocytic Hypophysitis: A Rare CaseChalothorn Wannaphut0Sakditad Saowapa1Vitchapong Prasitsumrit2Kamonkiat Wirunsawanya3Department of Medicine, John A. Burns School of Medicine University of Hawaii Honolulu Hawaii USADepartment of Medicine Texas Tech University Health Sciences Center Lubbock Texas USAFaculty of Medicine Siriraj Hospital Mahidol University Bangkok ThailandDivision of Endocrinology, Department of Medicine, John A. Burns School of Medicine University of Hawaii Honolulu Hawaii USAABSTRACT Postpartum autoimmune thyroiditis (PAT) and lymphocytic hypophysitis (LH) are rare autoimmune conditions occurring during or after pregnancy. We present a case of a 35‐year‐old woman who developed thyroid storm because of PAT followed by LH, resulting in panhypopituitarism. Initial presentation included hemodynamic instability, altered consciousness, and hyperthyroid symptoms. She was treated for thyroid storm and subsequently developed hypernatremia, suggestive of diabetes insipidus. MRI revealed features consistent with LH. This case highlights the complex interplay between immune dysregulation and pregnancy‐related hormonal changes, leading to concurrent autoimmune thyroiditis and hypophysitis. Prompt recognition and multidisciplinary management involving endocrinology, obstetrics, and critical care are essential for optimizing outcomes in such cases. Further research is needed to elucidate the underlying mechanisms and refine management strategies for these rare but potentially serious endocrine complications in the postpartum period.https://doi.org/10.1002/ccr3.9629autoimmunelymphocytic hypophysitispanhypopituitarismpostpartum thyroiditisthyroid storm |
| spellingShingle | Chalothorn Wannaphut Sakditad Saowapa Vitchapong Prasitsumrit Kamonkiat Wirunsawanya Concurrent Thyroid Storm From Postpartum Thyroiditis and Lymphocytic Hypophysitis: A Rare Case Clinical Case Reports autoimmune lymphocytic hypophysitis panhypopituitarism postpartum thyroiditis thyroid storm |
| title | Concurrent Thyroid Storm From Postpartum Thyroiditis and Lymphocytic Hypophysitis: A Rare Case |
| title_full | Concurrent Thyroid Storm From Postpartum Thyroiditis and Lymphocytic Hypophysitis: A Rare Case |
| title_fullStr | Concurrent Thyroid Storm From Postpartum Thyroiditis and Lymphocytic Hypophysitis: A Rare Case |
| title_full_unstemmed | Concurrent Thyroid Storm From Postpartum Thyroiditis and Lymphocytic Hypophysitis: A Rare Case |
| title_short | Concurrent Thyroid Storm From Postpartum Thyroiditis and Lymphocytic Hypophysitis: A Rare Case |
| title_sort | concurrent thyroid storm from postpartum thyroiditis and lymphocytic hypophysitis a rare case |
| topic | autoimmune lymphocytic hypophysitis panhypopituitarism postpartum thyroiditis thyroid storm |
| url | https://doi.org/10.1002/ccr3.9629 |
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