Primary Intraoral Granulocytic Sarcoma: A Case Report and Review of Literature
Granulocytic sarcoma (GS) is a rare extramedullary malignant tumor composed of immature granulocytes, including myeloblasts, promyelocytes, and myelocytes. In most cases, these are associated with persisting blood dyscrasias such as acute myeloid leukemia and chronic myeloid leukemia. To date, 32 ca...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical and Scientific Publishers Pvt. Ltd.
|
| Series: | Indian Journal of Medical and Paediatric Oncology |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791942 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850130191898116096 |
|---|---|
| author | Lamia Parveen Sudeshna Bagchi Rudra Prasad Chatterjee Abdul Mahmud Sangeeta Sinha |
| author_facet | Lamia Parveen Sudeshna Bagchi Rudra Prasad Chatterjee Abdul Mahmud Sangeeta Sinha |
| author_sort | Lamia Parveen |
| collection | DOAJ |
| description | Granulocytic sarcoma (GS) is a rare extramedullary malignant tumor composed of immature granulocytes, including myeloblasts, promyelocytes, and myelocytes. In most cases, these are associated with persisting blood dyscrasias such as acute myeloid leukemia and chronic myeloid leukemia. To date, 32 cases of GS involving orofacial region have been reported in the English literature. Out of these, only a few presented without any systemic complications. This case reports an unusual occurrence of GS without any associated leukemia involving the mandible of a 29-year-old male patient. Hematoxylin and eosin–stained sections revealed the presence of numerous rounds to ovoid myeloblasts with a multilobated, vesicular nucleus and a prominent nucleolus. The cells stained positive for Cluster of Differentiation 68, lysozyme, and myeloperoxidase. He later underwent chemotherapy but succumbed in the interim period of chemotherapy. We hereby report a unique case of GS of mandible in an apparently healthy individual who deteriorated rapidly; an early and accurate diagnosis of which could have been life-saving. |
| format | Article |
| id | doaj-art-0fed58b1da294eb69d8c451c55f7dec9 |
| institution | OA Journals |
| issn | 0971-5851 0975-2129 |
| language | English |
| publisher | Thieme Medical and Scientific Publishers Pvt. Ltd. |
| record_format | Article |
| series | Indian Journal of Medical and Paediatric Oncology |
| spelling | doaj-art-0fed58b1da294eb69d8c451c55f7dec92025-08-20T02:32:45ZengThieme Medical and Scientific Publishers Pvt. Ltd.Indian Journal of Medical and Paediatric Oncology0971-58510975-212910.1055/s-0044-1791942Primary Intraoral Granulocytic Sarcoma: A Case Report and Review of LiteratureLamia Parveen0Sudeshna Bagchi1https://orcid.org/0000-0002-7485-4143Rudra Prasad Chatterjee2Abdul Mahmud3Sangeeta Sinha4Department of Dentistry,Burdwan Medical College (WBUHS),Bardhaman, West Bengal, IndiaDepartment of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research (WBUHS),Kolkata, West Bengal, IndiaDepartment of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research (WBUHS),Kolkata, West Bengal, IndiaDepartment of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research (WBUHS),Kolkata, West Bengal, IndiaDepartment of Oral and Maxillofacial Pathology, Guru Nanak Institute of Dental Sciences and Research (WBUHS),Kolkata, West Bengal, IndiaGranulocytic sarcoma (GS) is a rare extramedullary malignant tumor composed of immature granulocytes, including myeloblasts, promyelocytes, and myelocytes. In most cases, these are associated with persisting blood dyscrasias such as acute myeloid leukemia and chronic myeloid leukemia. To date, 32 cases of GS involving orofacial region have been reported in the English literature. Out of these, only a few presented without any systemic complications. This case reports an unusual occurrence of GS without any associated leukemia involving the mandible of a 29-year-old male patient. Hematoxylin and eosin–stained sections revealed the presence of numerous rounds to ovoid myeloblasts with a multilobated, vesicular nucleus and a prominent nucleolus. The cells stained positive for Cluster of Differentiation 68, lysozyme, and myeloperoxidase. He later underwent chemotherapy but succumbed in the interim period of chemotherapy. We hereby report a unique case of GS of mandible in an apparently healthy individual who deteriorated rapidly; an early and accurate diagnosis of which could have been life-saving.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791942granulocytic sarcomamandibleMPOchemotherapy |
| spellingShingle | Lamia Parveen Sudeshna Bagchi Rudra Prasad Chatterjee Abdul Mahmud Sangeeta Sinha Primary Intraoral Granulocytic Sarcoma: A Case Report and Review of Literature Indian Journal of Medical and Paediatric Oncology granulocytic sarcoma mandible MPO chemotherapy |
| title | Primary Intraoral Granulocytic Sarcoma: A Case Report and Review of Literature |
| title_full | Primary Intraoral Granulocytic Sarcoma: A Case Report and Review of Literature |
| title_fullStr | Primary Intraoral Granulocytic Sarcoma: A Case Report and Review of Literature |
| title_full_unstemmed | Primary Intraoral Granulocytic Sarcoma: A Case Report and Review of Literature |
| title_short | Primary Intraoral Granulocytic Sarcoma: A Case Report and Review of Literature |
| title_sort | primary intraoral granulocytic sarcoma a case report and review of literature |
| topic | granulocytic sarcoma mandible MPO chemotherapy |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0044-1791942 |
| work_keys_str_mv | AT lamiaparveen primaryintraoralgranulocyticsarcomaacasereportandreviewofliterature AT sudeshnabagchi primaryintraoralgranulocyticsarcomaacasereportandreviewofliterature AT rudraprasadchatterjee primaryintraoralgranulocyticsarcomaacasereportandreviewofliterature AT abdulmahmud primaryintraoralgranulocyticsarcomaacasereportandreviewofliterature AT sangeetasinha primaryintraoralgranulocyticsarcomaacasereportandreviewofliterature |