Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics
Mesenchymal stem cells (MSCs) have been reported to possess regulatory functions on immune cells which make them alternative therapeutics for the treatment of inflammatory and autoimmune diseases. The interaction between MSCs and immune cells through paracrine factors might be crucial for these immu...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/5126156 |
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| author | Yoojin Seo Hyung-Sik Kim In-Sun Hong |
| author_facet | Yoojin Seo Hyung-Sik Kim In-Sun Hong |
| author_sort | Yoojin Seo |
| collection | DOAJ |
| description | Mesenchymal stem cells (MSCs) have been reported to possess regulatory functions on immune cells which make them alternative therapeutics for the treatment of inflammatory and autoimmune diseases. The interaction between MSCs and immune cells through paracrine factors might be crucial for these immunomodulatory effects of MSCs. Extracellular vesicles (EVs) are defined as bilayer membrane structures including exosomes and microvesicles which contain bioactive paracrine molecules affecting the characteristics of target cells. Recently, several studies have revealed that EVs derived from MSCs (MSC-EVs) can reproduce similar therapeutic impacts of parent MSCs; MSC-EVs could regulate proliferation, maturation, polarization, and migration of various immune effector cells and modulate the immune microenvironment depending on the context by delivering inflammatory cytokines, transcription factors, and microRNAs. Therefore, MSC-EVs can be applied as novel and promising tools for the treatment of immune-related disorders to overcome the limitations of conventional cell therapy regarding efficacy and toxicity issues. In this review, we will discuss current insights regarding the major outcomes in the evaluation of MSC-EV function against inflammatory disease models, as well as immune cells. |
| format | Article |
| id | doaj-art-0fe9b00d2ab94b609f84d20173b549d3 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-0fe9b00d2ab94b609f84d20173b549d32025-08-20T03:54:29ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/51261565126156Stem Cell-Derived Extracellular Vesicles as Immunomodulatory TherapeuticsYoojin Seo0Hyung-Sik Kim1In-Sun Hong2Institute of Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan 50612, Republic of KoreaInstitute of Translational Dental Sciences, School of Dentistry, Pusan National University, Yangsan 50612, Republic of KoreaLaboratory of Stem Cell Research, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Republic of KoreaMesenchymal stem cells (MSCs) have been reported to possess regulatory functions on immune cells which make them alternative therapeutics for the treatment of inflammatory and autoimmune diseases. The interaction between MSCs and immune cells through paracrine factors might be crucial for these immunomodulatory effects of MSCs. Extracellular vesicles (EVs) are defined as bilayer membrane structures including exosomes and microvesicles which contain bioactive paracrine molecules affecting the characteristics of target cells. Recently, several studies have revealed that EVs derived from MSCs (MSC-EVs) can reproduce similar therapeutic impacts of parent MSCs; MSC-EVs could regulate proliferation, maturation, polarization, and migration of various immune effector cells and modulate the immune microenvironment depending on the context by delivering inflammatory cytokines, transcription factors, and microRNAs. Therefore, MSC-EVs can be applied as novel and promising tools for the treatment of immune-related disorders to overcome the limitations of conventional cell therapy regarding efficacy and toxicity issues. In this review, we will discuss current insights regarding the major outcomes in the evaluation of MSC-EV function against inflammatory disease models, as well as immune cells.http://dx.doi.org/10.1155/2019/5126156 |
| spellingShingle | Yoojin Seo Hyung-Sik Kim In-Sun Hong Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics Stem Cells International |
| title | Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics |
| title_full | Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics |
| title_fullStr | Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics |
| title_full_unstemmed | Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics |
| title_short | Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics |
| title_sort | stem cell derived extracellular vesicles as immunomodulatory therapeutics |
| url | http://dx.doi.org/10.1155/2019/5126156 |
| work_keys_str_mv | AT yoojinseo stemcellderivedextracellularvesiclesasimmunomodulatorytherapeutics AT hyungsikkim stemcellderivedextracellularvesiclesasimmunomodulatorytherapeutics AT insunhong stemcellderivedextracellularvesiclesasimmunomodulatorytherapeutics |