Intercepting Modes of Cellular Communication
Metabolic homeostasis is maintained through a delicate balance of communication within and between multiple organ systems. These communication networks are essential for regulating nutrient intake, utilization, and storage. Conditions of metabolic dysfunction can impair proper tissue communication,...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X25000724 |
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| _version_ | 1849688207235481600 |
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| author | Kristin E. Claflin Matthew J. Potthoff |
| author_facet | Kristin E. Claflin Matthew J. Potthoff |
| author_sort | Kristin E. Claflin |
| collection | DOAJ |
| description | Metabolic homeostasis is maintained through a delicate balance of communication within and between multiple organ systems. These communication networks are essential for regulating nutrient intake, utilization, and storage. Conditions of metabolic dysfunction can impair proper tissue communication, which contributes to the progression of metabolic disease including obesity, hepatic steatosis, and type II diabetes. In this collection of Cellular and Molecular Gastroenterology and Hepatology, we highlight new advances in transcellular and interorgan communication, particularly in the liver and gastrointestinal (GI) tract, and how impairments in these biologic networks contribute to metabolic disease. In addition, we emphasize the therapeutic potential for modulating these communication pathways to treat metabolic disease. |
| format | Article |
| id | doaj-art-0fe8dc1102e3435a952fdbd2a2da86a2 |
| institution | DOAJ |
| issn | 2352-345X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj-art-0fe8dc1102e3435a952fdbd2a2da86a22025-08-20T03:22:04ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2025-01-0119810153110.1016/j.jcmgh.2025.101531Intercepting Modes of Cellular CommunicationKristin E. Claflin0Matthew J. Potthoff1Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, Iowa City, Iowa; Fraternal Order of Eagles Diabetes Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa; Iowa Neuroscience Institute, University of Iowa Carver College of Medicine, Iowa City, IowaDepartment of Veterans Affairs Medical Center, Oklahoma City, Oklahoma; Department of Biochemistry and Physiology, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma; Harold Hamm Diabetes Center, University of Oklahoma Health Sciences, Oklahoma City, Oklahoma; Correspondence Address correspondence to: Matthew J. Potthoff, PhD, University of Oklahoma Health Sciences Center, 1100 North Lindsay, Oklahoma City, Oklahoma.Metabolic homeostasis is maintained through a delicate balance of communication within and between multiple organ systems. These communication networks are essential for regulating nutrient intake, utilization, and storage. Conditions of metabolic dysfunction can impair proper tissue communication, which contributes to the progression of metabolic disease including obesity, hepatic steatosis, and type II diabetes. In this collection of Cellular and Molecular Gastroenterology and Hepatology, we highlight new advances in transcellular and interorgan communication, particularly in the liver and gastrointestinal (GI) tract, and how impairments in these biologic networks contribute to metabolic disease. In addition, we emphasize the therapeutic potential for modulating these communication pathways to treat metabolic disease.http://www.sciencedirect.com/science/article/pii/S2352345X25000724LiverHepatokinesCommunicationMetabolismMASHGut |
| spellingShingle | Kristin E. Claflin Matthew J. Potthoff Intercepting Modes of Cellular Communication Cellular and Molecular Gastroenterology and Hepatology Liver Hepatokines Communication Metabolism MASH Gut |
| title | Intercepting Modes of Cellular Communication |
| title_full | Intercepting Modes of Cellular Communication |
| title_fullStr | Intercepting Modes of Cellular Communication |
| title_full_unstemmed | Intercepting Modes of Cellular Communication |
| title_short | Intercepting Modes of Cellular Communication |
| title_sort | intercepting modes of cellular communication |
| topic | Liver Hepatokines Communication Metabolism MASH Gut |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X25000724 |
| work_keys_str_mv | AT kristineclaflin interceptingmodesofcellularcommunication AT matthewjpotthoff interceptingmodesofcellularcommunication |