Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site
ObjectiveThis study investigated the biomechanical properties of the dura mater from 29 Chinese adult donors (20 -86 years), focused on the influence of age, anatomical region, sex and loading direction, to establish Chinese population - specific material parameters for cranial finite element (FE) m...
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1550228/full |
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| author | Jinming Wang Jinming Wang Changsheng Cai Changsheng Cai Lei Wan Lei Wan Ao Liu Kaifei Deng Ying Fan Jianhua Zhang Jiang Huang Changwu Wan Donghua Zou Donghua Zou Zhengdong Li |
| author_facet | Jinming Wang Jinming Wang Changsheng Cai Changsheng Cai Lei Wan Lei Wan Ao Liu Kaifei Deng Ying Fan Jianhua Zhang Jiang Huang Changwu Wan Donghua Zou Donghua Zou Zhengdong Li |
| author_sort | Jinming Wang |
| collection | DOAJ |
| description | ObjectiveThis study investigated the biomechanical properties of the dura mater from 29 Chinese adult donors (20 -86 years), focused on the influence of age, anatomical region, sex and loading direction, to establish Chinese population - specific material parameters for cranial finite element (FE) models and enhance forensic traumatic brain injury analysis.MethodsIn this study, a total of 275 dural specimens were prepared and categorized into young adult (20-44 years), middle aged (45-64 years), and elderly (≥65 years) cohorts. Samples were excised from frontal, temporal, parietal and occipital regions and tested uniaxially in sagittal and coronal directions, with strain measured via digital image correlation (DIC) techniques. True stress-strain curves were fitted to the Raghavan model to determine elastic fiber modulus (EE), collagen fiber modulus (EC), failure stress (σTf), and failure strain (εTf); ultimate tensile force (MaxForce) was also recorded. Histological analysis assessed age-related microstructural changes.Resultsindicated significant age-related degradation: EC, σTf, εTf; and MaxForce significantly decreased with age (median EC declined from 28.0 MPa in young adults to 15.3 MPa in the elderly, P < 0.05; median εTf from 0.215 to 0.156, P < 0.05), while EE showed no significant age correlation (P = 0.10). Significant regional variance were observed, with the parietal region exhibiting higher EE (P = 0.01) and σTf (P = 0.03) compared to the occipital region; εTf showed no significant regional differences (P = 0.12). Dura mater demonstrated clear anisotropy: sagittal loading yielded significantly higher median EC (27.0 MPa vs. 18.1 MPa coronal, P = 0.003), σTf (4.30 MPa vs. 3.18 MPa coronal, P = 0.020), and MaxForce (12.9 N vs. 10.3 N coronal, P = 0.014). No statistically significant sex-based differences were found for any parameter (P > 0.05). Histology confirmed progressive age-related collagen disorganization and elastic fiber degradation. In conclusion, Chinese adult dura mater exhibits significant age-dependent decline in mechanical integrity, clear anisotropy favoring the sagittal direction, and notable regional heterogeneity, but no significant sex-based differences.ConclusionThese findings provide crucial, population-specific data for improving the biofidelity of FE head models and forensic injury analysis. |
| format | Article |
| id | doaj-art-0fe7ae8b5c944faea893644644ad246a |
| institution | DOAJ |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-0fe7ae8b5c944faea893644644ad246a2025-08-20T03:08:37ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-07-011310.3389/fbioe.2025.15502281550228Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical siteJinming Wang0Jinming Wang1Changsheng Cai2Changsheng Cai3Lei Wan4Lei Wan5Ao Liu6Kaifei Deng7Ying Fan8Jianhua Zhang9Jiang Huang10Changwu Wan11Donghua Zou12Donghua Zou13Zhengdong Li14Department of Forensic Medicine, School of Basic Medical Sciences, Fudan University, Shanghai, ChinaShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Guiyang, ChinaShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Guiyang, ChinaSchool of Forensic Medicine, Guizhou Medical University, Guiyang, ChinaShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Guiyang, ChinaDepartment of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, ChinaSchool of Electrical and Mechanical Engineering, Hunan University of Science and Technology, Xiangtan, ChinaShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Guiyang, ChinaShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Guiyang, ChinaShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Guiyang, ChinaSchool of Forensic Medicine, Guizhou Medical University, Guiyang, ChinaSchool of Forensic Medicine, Guizhou Medical University, Guiyang, ChinaShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Guiyang, ChinaSchool of Forensic Medicine, Guizhou Medical University, Guiyang, ChinaShanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Key Laboratory of Forensic Science, Ministry of Justice, Academy of Forensic Science, Guiyang, ChinaObjectiveThis study investigated the biomechanical properties of the dura mater from 29 Chinese adult donors (20 -86 years), focused on the influence of age, anatomical region, sex and loading direction, to establish Chinese population - specific material parameters for cranial finite element (FE) models and enhance forensic traumatic brain injury analysis.MethodsIn this study, a total of 275 dural specimens were prepared and categorized into young adult (20-44 years), middle aged (45-64 years), and elderly (≥65 years) cohorts. Samples were excised from frontal, temporal, parietal and occipital regions and tested uniaxially in sagittal and coronal directions, with strain measured via digital image correlation (DIC) techniques. True stress-strain curves were fitted to the Raghavan model to determine elastic fiber modulus (EE), collagen fiber modulus (EC), failure stress (σTf), and failure strain (εTf); ultimate tensile force (MaxForce) was also recorded. Histological analysis assessed age-related microstructural changes.Resultsindicated significant age-related degradation: EC, σTf, εTf; and MaxForce significantly decreased with age (median EC declined from 28.0 MPa in young adults to 15.3 MPa in the elderly, P < 0.05; median εTf from 0.215 to 0.156, P < 0.05), while EE showed no significant age correlation (P = 0.10). Significant regional variance were observed, with the parietal region exhibiting higher EE (P = 0.01) and σTf (P = 0.03) compared to the occipital region; εTf showed no significant regional differences (P = 0.12). Dura mater demonstrated clear anisotropy: sagittal loading yielded significantly higher median EC (27.0 MPa vs. 18.1 MPa coronal, P = 0.003), σTf (4.30 MPa vs. 3.18 MPa coronal, P = 0.020), and MaxForce (12.9 N vs. 10.3 N coronal, P = 0.014). No statistically significant sex-based differences were found for any parameter (P > 0.05). Histology confirmed progressive age-related collagen disorganization and elastic fiber degradation. In conclusion, Chinese adult dura mater exhibits significant age-dependent decline in mechanical integrity, clear anisotropy favoring the sagittal direction, and notable regional heterogeneity, but no significant sex-based differences.ConclusionThese findings provide crucial, population-specific data for improving the biofidelity of FE head models and forensic injury analysis.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1550228/fulldura materbiomechanicsmaterial propertiescraniocerebral injuryforensics |
| spellingShingle | Jinming Wang Jinming Wang Changsheng Cai Changsheng Cai Lei Wan Lei Wan Ao Liu Kaifei Deng Ying Fan Jianhua Zhang Jiang Huang Changwu Wan Donghua Zou Donghua Zou Zhengdong Li Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site Frontiers in Bioengineering and Biotechnology dura mater biomechanics material properties craniocerebral injury forensics |
| title | Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site |
| title_full | Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site |
| title_fullStr | Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site |
| title_full_unstemmed | Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site |
| title_short | Uniaxial tensile material properties of adult Chinese dura mater: investigating the influence of age, sex, and anatomical site |
| title_sort | uniaxial tensile material properties of adult chinese dura mater investigating the influence of age sex and anatomical site |
| topic | dura mater biomechanics material properties craniocerebral injury forensics |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1550228/full |
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