Symptomatic Primary (AL) Amyloidosis of the Stomach and Duodenum
Primary (AL) amyloidosis of the gastrointestinal tract is relatively rare, and symptomatic amyloidosis of the stomach is even more seldom. We present the case of a patient who was referred to upper endoscopy because of weight loss, nausea, and vomiting. Large areas of intramucosal hemorrhages were s...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Gastrointestinal Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/525439 |
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| author | Reidar Fossmark Espen Skarsvåg Harald Aarset Henrik Hjorth-Hansen Helge L. Waldum |
| author_facet | Reidar Fossmark Espen Skarsvåg Harald Aarset Henrik Hjorth-Hansen Helge L. Waldum |
| author_sort | Reidar Fossmark |
| collection | DOAJ |
| description | Primary (AL) amyloidosis of the gastrointestinal tract is relatively rare, and symptomatic amyloidosis of the stomach is even more seldom. We present the case of a patient who was referred to upper endoscopy because of weight loss, nausea, and vomiting. Large areas of intramucosal hemorrhages were seen, and biopsies resulted in profuse bleeding stopped with endoscopic clips. The biopsies showed amyloid depositions and further workup revealed that the patient also had cardiac and neuropathic involvements. The patient started treatment with dexamethasone, melphalan and bortezomib. After treatment was started the nausea and epigastric discomfort improved, and a reduction in the biochemical markers troponin T, NT-proBNP, and M-component was observed. Gastric amyloidosis is rarely seen at upper endoscopy in patients without a previously established diagnosis, but the unusual endoscopic findings and bleeding tendency after biopsy should be kept in mind by gastroenterologists. |
| format | Article |
| id | doaj-art-0fe794de8c0a4836b66adf1ec639d628 |
| institution | Kabale University |
| issn | 2090-6528 2090-6536 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Gastrointestinal Medicine |
| spelling | doaj-art-0fe794de8c0a4836b66adf1ec639d6282025-02-03T01:25:40ZengWileyCase Reports in Gastrointestinal Medicine2090-65282090-65362013-01-01201310.1155/2013/525439525439Symptomatic Primary (AL) Amyloidosis of the Stomach and DuodenumReidar Fossmark0Espen Skarsvåg1Harald Aarset2Henrik Hjorth-Hansen3Helge L. Waldum4Department of Gastroenterology and Hepatology, St. Olavs Hospital, Prinsesse Kristinas Gate 1, 7006 Trondheim, NorwayDepartment of Gastroenterology and Hepatology, St. Olavs Hospital, Prinsesse Kristinas Gate 1, 7006 Trondheim, NorwayDepartment of Pathology and Medical Genetics, St. Olavs Hospital, Erling Skjalgssons Gate 1, 7006 Trondheim, NorwayDepartment of Haematology, St. Olavs Hospital, Prinsesse Kristinas Gate 1, 7006 Trondheim, NorwayDepartment of Gastroenterology and Hepatology, St. Olavs Hospital, Prinsesse Kristinas Gate 1, 7006 Trondheim, NorwayPrimary (AL) amyloidosis of the gastrointestinal tract is relatively rare, and symptomatic amyloidosis of the stomach is even more seldom. We present the case of a patient who was referred to upper endoscopy because of weight loss, nausea, and vomiting. Large areas of intramucosal hemorrhages were seen, and biopsies resulted in profuse bleeding stopped with endoscopic clips. The biopsies showed amyloid depositions and further workup revealed that the patient also had cardiac and neuropathic involvements. The patient started treatment with dexamethasone, melphalan and bortezomib. After treatment was started the nausea and epigastric discomfort improved, and a reduction in the biochemical markers troponin T, NT-proBNP, and M-component was observed. Gastric amyloidosis is rarely seen at upper endoscopy in patients without a previously established diagnosis, but the unusual endoscopic findings and bleeding tendency after biopsy should be kept in mind by gastroenterologists.http://dx.doi.org/10.1155/2013/525439 |
| spellingShingle | Reidar Fossmark Espen Skarsvåg Harald Aarset Henrik Hjorth-Hansen Helge L. Waldum Symptomatic Primary (AL) Amyloidosis of the Stomach and Duodenum Case Reports in Gastrointestinal Medicine |
| title | Symptomatic Primary (AL) Amyloidosis of the Stomach and Duodenum |
| title_full | Symptomatic Primary (AL) Amyloidosis of the Stomach and Duodenum |
| title_fullStr | Symptomatic Primary (AL) Amyloidosis of the Stomach and Duodenum |
| title_full_unstemmed | Symptomatic Primary (AL) Amyloidosis of the Stomach and Duodenum |
| title_short | Symptomatic Primary (AL) Amyloidosis of the Stomach and Duodenum |
| title_sort | symptomatic primary al amyloidosis of the stomach and duodenum |
| url | http://dx.doi.org/10.1155/2013/525439 |
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