Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications

Clonorchis sinensis-driven hepatocarcinogenesis via E2F1-CD24 transcriptional axis: mechanistic and therapeutic implications

Abstract Background Hepatocellular carcinoma (HCC) remains a global health burden, with disproportionately high mortality in China’s Guangxi region, where endemic Clonorchis sinensis (C. sinensis) infection coincides with elevated HCC incidence. Preliminary single-cell sequencing revealed marked ove...

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Bibliographic Details
Main Authors: Wen-Min Lu, Jin Yan, Zhao-Ji Liu, Yong Wu, Qian-Ru Cui, Ji Feng, Yu Chen, Guang-Zhi Zhu, Tao Peng, Jing Zhou, Guo-Dong Lu
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Parasites & Vectors
Subjects:
Hepatocellular carcinoma
Clonorchis sinensis
CD24
E2F1
Tumor promotion
Online Access:https://doi.org/10.1186/s13071-025-06979-6
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