Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case report
Pemphigoid gestationis (PG) is well described in pregnancy, classically presenting as a pruritic, periumbilical rash in multiparous women in the second or third trimester.We describe a unique case of a woman with gestational trophoblastic neoplasia (GTN) status post dilation and curettage on methotr...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Gynecologic Oncology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352578925000967 |
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| author | Jasmine H. Wong Udele Tagoe Hatice B. Zengin Bijal Amin Beth N. McLellan Matthew Cowan |
| author_facet | Jasmine H. Wong Udele Tagoe Hatice B. Zengin Bijal Amin Beth N. McLellan Matthew Cowan |
| author_sort | Jasmine H. Wong |
| collection | DOAJ |
| description | Pemphigoid gestationis (PG) is well described in pregnancy, classically presenting as a pruritic, periumbilical rash in multiparous women in the second or third trimester.We describe a unique case of a woman with gestational trophoblastic neoplasia (GTN) status post dilation and curettage on methotrexate (MTX) who presented with a diffuse, pruritic rash. After the rash persisted and flared despite multiple cycles of MTX, biopsies were obtained supporting a diagnosis of PG.It is important to consider PG on the differential in non-pregnant patients with GTN with a persistent pruritic rash, even in the setting of ongoing treatment with MTX. |
| format | Article |
| id | doaj-art-0fdd5a49737c4ceca015121132e30c50 |
| institution | Kabale University |
| issn | 2352-5789 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gynecologic Oncology Reports |
| spelling | doaj-art-0fdd5a49737c4ceca015121132e30c502025-08-20T03:30:51ZengElsevierGynecologic Oncology Reports2352-57892025-06-015910177110.1016/j.gore.2025.101771Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case reportJasmine H. Wong0Udele Tagoe1Hatice B. Zengin2Bijal Amin3Beth N. McLellan4Matthew Cowan5Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA; Corresponding author at: 3411 Wayne Ave., Bronx, NY 10467, USA.Division of Gynecologic Oncology, Department of Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, Montefiore Medical Center, USADivision of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA; Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USADivision of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA; Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USADivision of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USADivision of Gynecologic Oncology, Department of Obstetrics & Gynecology and Women’s Health, Albert Einstein College of Medicine, Montefiore Medical Center, USAPemphigoid gestationis (PG) is well described in pregnancy, classically presenting as a pruritic, periumbilical rash in multiparous women in the second or third trimester.We describe a unique case of a woman with gestational trophoblastic neoplasia (GTN) status post dilation and curettage on methotrexate (MTX) who presented with a diffuse, pruritic rash. After the rash persisted and flared despite multiple cycles of MTX, biopsies were obtained supporting a diagnosis of PG.It is important to consider PG on the differential in non-pregnant patients with GTN with a persistent pruritic rash, even in the setting of ongoing treatment with MTX.http://www.sciencedirect.com/science/article/pii/S2352578925000967Pemphigoid gestationisGestational trophoblastic neoplasiaMethotrexate |
| spellingShingle | Jasmine H. Wong Udele Tagoe Hatice B. Zengin Bijal Amin Beth N. McLellan Matthew Cowan Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case report Gynecologic Oncology Reports Pemphigoid gestationis Gestational trophoblastic neoplasia Methotrexate |
| title | Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case report |
| title_full | Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case report |
| title_fullStr | Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case report |
| title_full_unstemmed | Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case report |
| title_short | Pemphigoid gestationis associated with gestational trophoblastic neoplasia: A case report |
| title_sort | pemphigoid gestationis associated with gestational trophoblastic neoplasia a case report |
| topic | Pemphigoid gestationis Gestational trophoblastic neoplasia Methotrexate |
| url | http://www.sciencedirect.com/science/article/pii/S2352578925000967 |
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