Recent advances in the development and application of colorectal cancer mouse models
Colorectal cancer (CRC) remains a significant global health challenge, necessitating the development of reliable preclinical models to advance mechanistic understanding and therapeutic innovation. This review comprehensively examines the diverse spectrum of rodent models employed in CRC research, fo...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1553637/full |
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| _version_ | 1850194080160546816 |
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| author | Ting Wang Ting Wang Zhen Chen Yuli Zhang Min Liu Hua Sui Qingfeng Tang |
| author_facet | Ting Wang Ting Wang Zhen Chen Yuli Zhang Min Liu Hua Sui Qingfeng Tang |
| author_sort | Ting Wang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) remains a significant global health challenge, necessitating the development of reliable preclinical models to advance mechanistic understanding and therapeutic innovation. This review comprehensively examines the diverse spectrum of rodent models employed in CRC research, focusing on their unique characteristics, applications, and translational relevance. We systematically evaluate conventional models, including carcinogen-induced models and genetically engineered mouse models (GEMMs), which have been instrumental in elucidating tumorigenic pathways and genetic drivers. Furthermore, we highlight the emergence of patient-derived xenografts (PDX) as a transformative tool for recapitulating tumor heterogeneity and predicting clinical responses. The review also explores metastatic models, which are critical for studying advanced disease, and spontaneous models that mimic natural tumor progression. Additionally, we discuss the growing utility of composite animal models, which integrate multiple methodologies to better reflect the complexity of human CRC. By comparing the strengths and limitations of each model system, this review provides a framework for selecting appropriate models based on specific research objectives. Collectively, these preclinical platforms have significantly advanced our understanding of CRC biology and continue to drive the development of targeted therapies and personalized treatment strategies. |
| format | Article |
| id | doaj-art-0fda76d93dda48e58dc17d0315730e85 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-0fda76d93dda48e58dc17d0315730e852025-08-20T02:14:06ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15536371553637Recent advances in the development and application of colorectal cancer mouse modelsTing Wang0Ting Wang1Zhen Chen2Yuli Zhang3Min Liu4Hua Sui5Qingfeng Tang6Nanxiang Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaShanghai University of Traditional Chinese Medicine, Shanghai, ChinaThe Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou, ChinaJiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNanxiang Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaJiading Branch of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaNanxiang Branch of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaColorectal cancer (CRC) remains a significant global health challenge, necessitating the development of reliable preclinical models to advance mechanistic understanding and therapeutic innovation. This review comprehensively examines the diverse spectrum of rodent models employed in CRC research, focusing on their unique characteristics, applications, and translational relevance. We systematically evaluate conventional models, including carcinogen-induced models and genetically engineered mouse models (GEMMs), which have been instrumental in elucidating tumorigenic pathways and genetic drivers. Furthermore, we highlight the emergence of patient-derived xenografts (PDX) as a transformative tool for recapitulating tumor heterogeneity and predicting clinical responses. The review also explores metastatic models, which are critical for studying advanced disease, and spontaneous models that mimic natural tumor progression. Additionally, we discuss the growing utility of composite animal models, which integrate multiple methodologies to better reflect the complexity of human CRC. By comparing the strengths and limitations of each model system, this review provides a framework for selecting appropriate models based on specific research objectives. Collectively, these preclinical platforms have significantly advanced our understanding of CRC biology and continue to drive the development of targeted therapies and personalized treatment strategies.https://www.frontiersin.org/articles/10.3389/fphar.2025.1553637/fullcolorectal canceranimal modelpatient-derived xenograftscarcinogen-induced modelsgenetically engineered mouse modelsmetastatic model |
| spellingShingle | Ting Wang Ting Wang Zhen Chen Yuli Zhang Min Liu Hua Sui Qingfeng Tang Recent advances in the development and application of colorectal cancer mouse models Frontiers in Pharmacology colorectal cancer animal model patient-derived xenografts carcinogen-induced models genetically engineered mouse models metastatic model |
| title | Recent advances in the development and application of colorectal cancer mouse models |
| title_full | Recent advances in the development and application of colorectal cancer mouse models |
| title_fullStr | Recent advances in the development and application of colorectal cancer mouse models |
| title_full_unstemmed | Recent advances in the development and application of colorectal cancer mouse models |
| title_short | Recent advances in the development and application of colorectal cancer mouse models |
| title_sort | recent advances in the development and application of colorectal cancer mouse models |
| topic | colorectal cancer animal model patient-derived xenografts carcinogen-induced models genetically engineered mouse models metastatic model |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1553637/full |
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