The Spectrophotometric Determination of Famotidine Drug via Coupling with Diazotized Metochlopramide Hydrochloride
A new, simple and sensitive spectrophotometric method was described for the determination of famotidine (FAM) as a pure material and in pharmaceutical formulation. This method was based on diazotization and coupling reaction between famotidine and diazotized solution of metochlopramide hydrochloride...
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University of Baghdad, College of Science for Women
2015-12-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2121 |
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| description | A new, simple and sensitive spectrophotometric method was described for the determination of famotidine (FAM) as a pure material and in pharmaceutical formulation. This method was based on diazotization and coupling reaction between famotidine and diazotized solution of metochlopramide hydrochloride (DMPH) in the presence of phosphate buffer solution to give a compound of azo dye having orange color soluble in water with high absorptivity at a wave length of 478 nm. The data shows that FAM and DMPH combine in the molar ratio of 1:1 at PH 7.0 .The method obeys Beer's law over concentration range of 1-40 ?g.ml-1 of famotidine with a correlation coefficient of 0.9955 and a detection limit of 0.10 ?g.ml-1. The apparent molar absorptivity referred to famotidine has been found to be 2.0 x 104 L. mol-1cm. -1. The proposed method was applied successfully to the assay of famotidine in pharmaceutical preparation. |
| format | Article |
| id | doaj-art-0fd83750cb814dce94e304e472e69745 |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2015-12-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-0fd83750cb814dce94e304e472e697452025-08-20T03:58:10ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862015-12-0112410.21123/bsj.12.4.730-739The Spectrophotometric Determination of Famotidine Drug via Coupling with Diazotized Metochlopramide HydrochlorideBaghdad Science JournalA new, simple and sensitive spectrophotometric method was described for the determination of famotidine (FAM) as a pure material and in pharmaceutical formulation. This method was based on diazotization and coupling reaction between famotidine and diazotized solution of metochlopramide hydrochloride (DMPH) in the presence of phosphate buffer solution to give a compound of azo dye having orange color soluble in water with high absorptivity at a wave length of 478 nm. The data shows that FAM and DMPH combine in the molar ratio of 1:1 at PH 7.0 .The method obeys Beer's law over concentration range of 1-40 ?g.ml-1 of famotidine with a correlation coefficient of 0.9955 and a detection limit of 0.10 ?g.ml-1. The apparent molar absorptivity referred to famotidine has been found to be 2.0 x 104 L. mol-1cm. -1. The proposed method was applied successfully to the assay of famotidine in pharmaceutical preparation.http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2121Famotidine, Spectrophotometric determination, Metochlopramide, Diazotization and coupling |
| spellingShingle | Baghdad Science Journal The Spectrophotometric Determination of Famotidine Drug via Coupling with Diazotized Metochlopramide Hydrochloride مجلة بغداد للعلوم Famotidine, Spectrophotometric determination, Metochlopramide, Diazotization and coupling |
| title | The Spectrophotometric Determination of Famotidine Drug via Coupling with Diazotized Metochlopramide Hydrochloride |
| title_full | The Spectrophotometric Determination of Famotidine Drug via Coupling with Diazotized Metochlopramide Hydrochloride |
| title_fullStr | The Spectrophotometric Determination of Famotidine Drug via Coupling with Diazotized Metochlopramide Hydrochloride |
| title_full_unstemmed | The Spectrophotometric Determination of Famotidine Drug via Coupling with Diazotized Metochlopramide Hydrochloride |
| title_short | The Spectrophotometric Determination of Famotidine Drug via Coupling with Diazotized Metochlopramide Hydrochloride |
| title_sort | spectrophotometric determination of famotidine drug via coupling with diazotized metochlopramide hydrochloride |
| topic | Famotidine, Spectrophotometric determination, Metochlopramide, Diazotization and coupling |
| url | http://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/2121 |
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