Tip60 HAT activators as therapeutic modulators for Alzheimer’s disease

Tip60 HAT activators as therapeutic modulators for Alzheimer’s disease

Abstract Reduced histone acetylation in the brain causes transcriptional dysregulation and cognitive impairment that are key initial steps in Alzheimer’s disease (AD) etiology. Unfortunately, current treatment strategies primarily focus on histone deacetylase inhibition (HDACi) that causes detriment...

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Bibliographic Details
Main Authors: Akanksha Bhatnagar, Christina M. Thomas, Gu Gu Nge, Aprem Zaya, Rohan Dasari, Neha Chongtham, Bijaya Manandhar, Sandhya Kortagere, Felice Elefant
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58496-w
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