Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms
Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patie...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/5491465 |
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| _version_ | 1832556724646576128 |
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| author | Fengyuan Li Kangmin Duan Cuiling Wang Craig McClain Wenke Feng |
| author_facet | Fengyuan Li Kangmin Duan Cuiling Wang Craig McClain Wenke Feng |
| author_sort | Fengyuan Li |
| collection | DOAJ |
| description | Despite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in animals with experimental ALD in the past, there is still no FDA (Food and Drug Administration) approved therapy for any stage of ALD. With the increasing recognition of the importance of gut microbiota in the onset and development of a variety of diseases, the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients. Potential mechanisms underlying the probiotic function are also discussed. |
| format | Article |
| id | doaj-art-0fd5692cc54e4eff8da6d51ef35e1fa4 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-0fd5692cc54e4eff8da6d51ef35e1fa42025-02-03T05:44:28ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/54914655491465Probiotics and Alcoholic Liver Disease: Treatment and Potential MechanismsFengyuan Li0Kangmin Duan1Cuiling Wang2Craig McClain3Wenke Feng4College of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, ChinaCollege of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, ChinaCollege of Life Sciences, Northwest University, Xi’an, Shaanxi 710069, ChinaDepartments of Medicine, Pharmacology and Toxicology, University of Louisville School of Medicine, Louisville, KY 40202, USASchool of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, ChinaDespite extensive research, alcohol remains one of the most common causes of liver disease in the United States. Alcoholic liver disease (ALD) encompasses a broad spectrum of disorders, including steatosis, steatohepatitis, and cirrhosis. Although many agents and approaches have been tested in patients with ALD and in animals with experimental ALD in the past, there is still no FDA (Food and Drug Administration) approved therapy for any stage of ALD. With the increasing recognition of the importance of gut microbiota in the onset and development of a variety of diseases, the potential use of probiotics in ALD is receiving increasing investigative and clinical attention. In this review, we summarize recent studies on probiotic intervention in the prevention and treatment of ALD in experimental animal models and patients. Potential mechanisms underlying the probiotic function are also discussed.http://dx.doi.org/10.1155/2016/5491465 |
| spellingShingle | Fengyuan Li Kangmin Duan Cuiling Wang Craig McClain Wenke Feng Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms Gastroenterology Research and Practice |
| title | Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms |
| title_full | Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms |
| title_fullStr | Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms |
| title_full_unstemmed | Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms |
| title_short | Probiotics and Alcoholic Liver Disease: Treatment and Potential Mechanisms |
| title_sort | probiotics and alcoholic liver disease treatment and potential mechanisms |
| url | http://dx.doi.org/10.1155/2016/5491465 |
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