Development and evaluation of mPEG-PLLA polymeric micelles encapsulating enrofloxacin for enhanced solubility, bioavailability, and antibacterial performance

Development and evaluation of mPEG-PLLA polymeric micelles encapsulating enrofloxacin for enhanced solubility, bioavailability, and antibacterial performance

The aim of this study was to prepare polymeric micelles composed of enrofloxacin (ENR) and methoxy poly (ethylene glycol)-poly(lactide) (mPEG-PLLA) using a solvent evaporation method to overcome the solubility-limited oral bioavailability of ENR. The formulation was optimized using a Box–Behnken des...

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Bibliographic Details
Main Authors: Yanling Sun, Yanan Mao, Xin He, Xinghua Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Veterinary Science
Subjects:
enrofloxacin
MPEG-PLLA
micelles
oral bioavailability
antibacterial activity
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1595137/full
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