MODERN PATHOLOGICAL CONSTELLATION FOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS AND IMMUNOHISTOCHEMICAL PANEL
Purpose: Gastroenteropancreatic neuroendocrine tumors are heterogeneous group of tumors. The pathomorphological assessment is essential for the staging and requires an immunohistochemical panel of several markers for validation.The aim of the article is to summarize pathological constellation for...
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Trakia University
2022-12-01
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| Series: | Trakia Journal of Sciences |
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| Online Access: | http://tru.uni-sz.bg/tsj/Volume%2020,%202022,%20Numbe%204,%20Series%20Biomedical%20Sciences/10_P.Vladova.pdf |
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| author | P. Vladova |
| author_facet | P. Vladova |
| author_sort | P. Vladova |
| collection | DOAJ |
| description | Purpose: Gastroenteropancreatic neuroendocrine tumors are heterogeneous group of tumors. The
pathomorphological assessment is essential for the staging and requires an immunohistochemical panel of
several markers for validation.The aim of the article is to summarize pathological constellation for
neuroendocrine tumor and immunohistochemical panel.
Methods: Critical evaluation of the data available from existing studies.
Results: Current immunohistochemical diagnostic markers include synaptophysin, chromogranin, and Ki-67
index. The ability of SSRs to be internalized in the development of radiolabeled somatostatin analogues has
further contributed to improved diagnosis and treatment of NETs.
Conclusion: Nowadays, there has been a significant increase in the number of molecularly targeted agents in
the treatment of neuroendocrine tumors. |
| format | Article |
| id | doaj-art-0fd276c6c32541d8afa974ae797b4e2a |
| institution | DOAJ |
| issn | 1313-3551 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Trakia University |
| record_format | Article |
| series | Trakia Journal of Sciences |
| spelling | doaj-art-0fd276c6c32541d8afa974ae797b4e2a2025-08-20T02:54:54ZengTrakia UniversityTrakia Journal of Sciences1313-35512022-12-0120434635310.15547/tjs.2022.04.010MODERN PATHOLOGICAL CONSTELLATION FOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS AND IMMUNOHISTOCHEMICAL PANELP. VladovaPurpose: Gastroenteropancreatic neuroendocrine tumors are heterogeneous group of tumors. The pathomorphological assessment is essential for the staging and requires an immunohistochemical panel of several markers for validation.The aim of the article is to summarize pathological constellation for neuroendocrine tumor and immunohistochemical panel. Methods: Critical evaluation of the data available from existing studies. Results: Current immunohistochemical diagnostic markers include synaptophysin, chromogranin, and Ki-67 index. The ability of SSRs to be internalized in the development of radiolabeled somatostatin analogues has further contributed to improved diagnosis and treatment of NETs. Conclusion: Nowadays, there has been a significant increase in the number of molecularly targeted agents in the treatment of neuroendocrine tumors.http://tru.uni-sz.bg/tsj/Volume%2020,%202022,%20Numbe%204,%20Series%20Biomedical%20Sciences/10_P.Vladova.pdfgastroenteropancreatic neuroendocrine tumorsimmunohistochemistry |
| spellingShingle | P. Vladova MODERN PATHOLOGICAL CONSTELLATION FOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS AND IMMUNOHISTOCHEMICAL PANEL Trakia Journal of Sciences gastroenteropancreatic neuroendocrine tumors immunohistochemistry |
| title | MODERN PATHOLOGICAL CONSTELLATION FOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS AND IMMUNOHISTOCHEMICAL PANEL |
| title_full | MODERN PATHOLOGICAL CONSTELLATION FOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS AND IMMUNOHISTOCHEMICAL PANEL |
| title_fullStr | MODERN PATHOLOGICAL CONSTELLATION FOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS AND IMMUNOHISTOCHEMICAL PANEL |
| title_full_unstemmed | MODERN PATHOLOGICAL CONSTELLATION FOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS AND IMMUNOHISTOCHEMICAL PANEL |
| title_short | MODERN PATHOLOGICAL CONSTELLATION FOR GASTROENTEROPANCREATIC NEUROENDOCRINE TUMORS AND IMMUNOHISTOCHEMICAL PANEL |
| title_sort | modern pathological constellation for gastroenteropancreatic neuroendocrine tumors and immunohistochemical panel |
| topic | gastroenteropancreatic neuroendocrine tumors immunohistochemistry |
| url | http://tru.uni-sz.bg/tsj/Volume%2020,%202022,%20Numbe%204,%20Series%20Biomedical%20Sciences/10_P.Vladova.pdf |
| work_keys_str_mv | AT pvladova modernpathologicalconstellationforgastroenteropancreaticneuroendocrinetumorsandimmunohistochemicalpanel |